...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Inhalation toxicology >No adverse lung effects of 7- and 28-day inhalation exposure of rats to emissions from petrodiesel fuel containing 20% rapeseed methyl esters (B20) with and without particulate filter - the FuelHealth project
【24h】

No adverse lung effects of 7- and 28-day inhalation exposure of rats to emissions from petrodiesel fuel containing 20% rapeseed methyl esters (B20) with and without particulate filter - the FuelHealth project

机译：7-和28天吸入大鼠对含有20％菜籽甲基酯（B20）的燃料燃料的排放的不良肺部效应，含有颗粒式过滤器 - 燃料健康项目

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Increased use of biofuels raises concerns about health effects of new emissions. We analyzed relative lung health effects, on Fisher 344 rats, of diesel engine exhausts emissions (DEE) from a Euro 5-classi-fied diesel engine running on petrodiesel fuel containing 20% rapeseed methyl esters (B20) with and without diesel particulate filter (DPF). One group of animals was exposed to DEE for 7 days (6h/day), and another group for 28 days (6h/day, 5 days/week), both with and without DPF. The animals {n — 7/ treatment) were exposed in whole body exposure chambers. Animals breathing clean air were used as controls. Genotoxic effects of the lungs by the Comet assay, histological examination of lung tissue, bronchoalveolar lavage fluid (BALF) markers of pulmonary injury, and mRNA markers of inflammation and oxidative stress were analyzed. Our results showed that a minor number of genes related to inflammation were slightly differently expressed in the exposed animals compared to control. Histological analysis also revealed only minor effects on inflammatory tissue markers in the lungs, and this was supported by flow cytometry and ELISA analysis of cytokines in BALF. No exposure-related indications of genotoxicity were observed. Overall, exposure to DEE with or without DPF technology produced no adverse effects in the endpoints analyzed in the rat lung tissue or the BALF. Overall, exposure to DEE from a modern Euro 5 light vehicle engine run on B20 fuel with or without DPF technology produced no adverse effects in the endpoints analyzed in the rat lung tissue or the BALF.
机译：增加使用生物燃料会引发对新排放的健康影响的担忧。我们分析了柴油发动机排放排放（DEE）的柴油机344大鼠的相对肺部健康效应，从欧元5分类的柴油发动机上运行含有20％油菜籽甲酯（B20）的欧元5分类的柴油发动机，其中没有柴油颗粒过滤器（ DPF）。将一组动物暴露于DEE 7天（6小时/天），另一组（6小时/天）28天（6小时/天，5天/周），无论是否有DPF。将动物{N - 7 /处理）暴露在全身曝光室中。呼吸清洁空气的动物用作对照。通过彗星测定，肺组织的组织学检查，肺损伤的组织学检查，肺损伤的支气管肺血液（BALF）标记，以及炎症和氧化胁迫的mRNA标志物的组织学检查。我们的研究结果表明，与对照相比，在暴露的动物中，在暴露的动物中表达了与炎症有关的少数基因。组织学分析还仅显示对肺中炎性组织标志物的微小影响，这是通过流式细胞术和BALF细胞因子的eLISA分析来支持的。没有观察到与遗传毒性的曝光相关的迹象。总体而言，在大鼠肺组织或BALF中分析的终点没有产生与或不具有DPF技术的脱果。总体而言，从现代欧元5欧欧元的DEE接触在B20燃料上运行或没有DPF技术在大鼠肺组织或BALF中的终点中产生不利影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号