...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Inhalation toxicology >Repeated dose inhalation developmental toxicity study in rats exposed to cellulose insulation with boric acid additive
【24h】

Repeated dose inhalation developmental toxicity study in rats exposed to cellulose insulation with boric acid additive

机译：用硼酸添加剂暴露于纤维素绝缘的大鼠的重复剂量吸入发育毒性研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cellulose insulation (CI), a common building material, is a mixture of cellulose fibers and borates. Borates are approximately 20% of the product weight and act as a flame retardant. Given possible exposure to workers and consumers, an inhalation toxicity study was conducted following Organization for Economic Co-operation and Development (OECD) 414 for Prenatal Development Toxicity to evaluate if CI is a developmental toxicant. Pregnant female rats were exposed by nose-only inhalation to CI aerosols containing 20% boric acid for six h/day, from gestational day (GD) 6-19, and fetuses were evaluated for developmental parameters. Respirable CI was produced by grinding to produce respirable particles (MMAD 2.7-2.9 mu m, geometric standard deviations (GSD) 1.9-2.6), which were then aerosolized. Target air concentrations were 15, 90, and 270mg CI/m(3). Controls were exposed to air only. Slight body weight reductions (average decrease <7% vs. control) were observed in male and female GD 20 fetuses in the mid and high dose groups. No embryo/fetal developmental toxicity or alterations in any other measured variable were reported at any dose. The no observed adverse effect level (NOAEL) for developmental outcomes was 270mg/m(3).
机译：纤维素绝缘（CI），一种共同的建筑材料是纤维素纤维和硼酸盐的混合物。硼酸盐约为产物重量的20％，并充当阻燃剂。鉴于工人和消费者可能接触，在经济合作和开发组织下进行吸入毒性研究，用于评估毒性的产前发育毒性，如果CI是一种发育毒性，则进行毒性。孕妇雌性大鼠仅通过仅鼻子吸入到含有20％硼酸的CI气溶胶，从妊娠期（GD）6-19，评价胎儿进行发育参数。通过研磨以产生可吸入颗粒（MMAD 2.7-2.9 mu M，几何标准偏差（GSD）1.9-2.6）来生产可吸入的CI，然后是雾化的。目标空气浓度为15,90和270mg / m（3）。控制仅暴露在空中。在中高剂量基团中的​​雄性和雌性Gd 20胎儿中观察到轻微的体重减少（平均降低<7％对照）。在任何剂量下报告任何其他测量变量中的胚胎/胎儿发育毒性或改变。没有观察到的发育结果的不良反应水平（NOAEL）是270mg / m（3）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号