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首页> 外文期刊>BJU international >The role of vitamin A in preventing renal scarring secondary to pyelonephritis.
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The role of vitamin A in preventing renal scarring secondary to pyelonephritis.

机译：维生素A在预防继发于肾盂肾炎的肾脏瘢痕形成中的作用。

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OBJECTIVE: To evaluate the efficiency of exogenously administered vitamin A in preventing renal scarring caused by experimental pyelonephritis in rats. MATERIALS AND METHODS: Forty Wistar rats were injected with 0.1 mL of solution containing Escherichia coli (1010 /mL) into both renal medullae. Five equal groups were then formed: group 1 was treated only with ciprofloxacin (30 mg/kg per day, twice daily, intraperitoneally) for 5 days, starting 3 days after bacterial inoculation; in group 2, 60 kIU of vitamin A was injected intramuscularly with the bacterial inoculation; in group 3, 60 kIU of vitamin A was injected similarly, but 3 days after bacterial inoculation; in group 4, 60 kIU of vitamin A was given orally with the bacterial inoculation; and group 5 was treated with ciprofloxacin for 5 days and vitamin A intramuscularly from the third day after bacterial inoculation. All the rats were killed 6 weeks after bacterial injection; blood samples were obtained to determine serum vitamin A and beta-carotene levels, and both kidneys were examined pathologically for scarring, graded as 0 (none), 1 (mild), 2 (moderate) and 3 (severe). RESULTS: Serum vitamin A levels were higher in the rats given vitamin A (group 2-5) than in group 1, being highest in group 4, although only this group had significantly higher levels of vitamin A than group 1 (P<0.05). Histopathologically, the fibrosis was mildest in groups 2 and 4 (two of 16 kidneys grade 1), whereas it was most severe in group 1 (all 16 grade 2-3). Fibrosis was significantly less in groups 2-5 than in group 1 (P<0.05). There was a significant negative correlation between vitamin A levels and the sum of the fibrosis, inflammation and tubular atrophy scores of all rats (r=-0.391, P<0.02). beta-carotene levels were unrelated to renal scarring. CONCLUSION: The administration of vitamin A could have a role in preventing renal scar formation from pyelonephritis induced experimentally in rats.
机译：目的：评价外用维生素A预防大鼠实验性肾盂肾炎所致肾脏瘢痕形成的效果。材料与方法：40只Wistar大鼠分别向肾髓质中注射0.1 mL含大肠杆菌的溶液（1010 / mL）。然后形成五个相等的组：第1组仅在细菌接种后3天开始用环丙沙星（每天30 mg / kg，每天两次，腹膜内）治疗5天。在第2组中，通过细菌接种肌肉注射60 kIU的维生素A。在第3组中，在细菌接种后3天类似地注射60 kIU维生素A。在第4组中，通过细菌接种口服60 kIU维生素A;从细菌接种后的第三天开始，第5组接受环丙沙星治疗5天，肌肉注射维生素A。细菌注射后6周，将所有大鼠处死。采集血液样本以确定血清维生素A和β-胡萝卜素水平，并通过病理学检查两个肾脏的瘢痕形成，等级分别为0（无），1（轻度），2（中度）和3（严重）。结果：给予维生素A的大鼠（2-5组）血清维生素A水平高于第1组，在第4组最高，尽管只有该组的维生素A水平明显高于第1组（P <0.05） 。在组织病理学上，第2组和第4组的纤维化最轻（16个1级肾脏中的2个），而第1组的纤维化最严重（所有16个2-3级肾脏）。 2-5组的纤维化明显少于1组（P <0.05）。所有大鼠的维生素A水平与纤维化，炎症和肾小管萎缩总和之间存在显着的负相关性（r = -0.391，P <0.02）。 β-胡萝卜素水平与肾脏瘢痕形成无关。结论：维生素A的给药可能具有预防大鼠肾盂肾炎形成瘢痕的作用。

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