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首页> 外文期刊>Internal medicine journal >Natural killer cells--new understanding of basic biology may lead to more effective allogeneic haematopoietic stem cell transplantation.
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Natural killer cells--new understanding of basic biology may lead to more effective allogeneic haematopoietic stem cell transplantation.

机译：天然杀手细胞 - 对基本生物学的新理解可能导致更有效的同种异体血液生物干细胞移植。

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The natural killer (NK) cells are part of the innate immune system and are responsible for initial defences in the surveillance against malignant cells and virally infected cells. In addition to direct cytotoxicity, cytokines produced by NK cells amplify the immune response and help control the neoplasm/pathogen. Several activating and inhibitory receptors responsible for NK cell activation are recently characterized and play a crucial role in tumour eradication. These include, but are not limited to, the killer immunoglobulin-like receptors, C-type lectin receptors and natural cytotoxicity receptors. The downstream signalling of some of these receptors is also characterized. The net balance in the sum of the signals generated by ligation of activating and inhibitory receptors determines the final outcome, cytotoxicity versus tolerance. NK cell-based immunotherapy can be successfully exploited in the haematopoietic stem cell transplantation for the treatment of haematological malignancies and has a potential to separate the beneficial graft versus leukaemia effect from, often dangerous, graft versus host disease. This article reviews the NK receptors important in NK-mediated cytotoxicity in allogeneic haematopoietic stem cell transplantation.
机译：天然杀伤（NK）细胞是先天免疫系统的一部分，负责对恶性细胞和病毒感染细胞进行监测的初始防御。除了直接细胞毒性外，NK细胞产生的细胞因子还会扩增免疫应答并有助于控制肿瘤/病原体。最近表征了几种负责NK细胞活化的活化和抑制受体，并在肿瘤根除中发挥至关重要的作用。这些包括但不限于杀手免疫球蛋白样受体，C型凝集素受体和天然细胞毒性受体。一些这些受体的下游信号传导也表征。通过结扎激活和抑制性受体产生的信号之和中的净平衡决定了最终结果，细胞毒性与耐受性。基于NK细胞的免疫疗法可以成功地利用血臭干细胞移植治疗血液恶性肿瘤，并且有可能与白血病效应分离，通常危险，移植物与宿主病。本文综述了异基因血液干细胞移植中NK介导的细胞毒性的NK受体。

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