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首页> 外文期刊>International immunology. >Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy.
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Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy.

机译：在化学疗法后，增加了IgG1，IFN-γ，TNF-α和IL-6对结核病患者的结核分枝杆菌抗原的反应。

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摘要

Detection of specific antibodies may represent an additional tool in diagnosis of tuberculosis (TB). Herein, levels of serum IgG antibodies against early secreted antigenic target (ESAT-6), culture filtrate antigen-10 (CFP-10) and 16 kDa Mycobacterium tuberculosis antigens were measured in 33 active pulmonary TB patients (0M-TB), in 47 patients after 1-3 months of treatment (3M-TB) and in 22 patients who had completed 6 months of chemotherapy (6M-TB). The control group consisted of 38 BCG-vaccinated healthy controls (HC). In addition, IFN-gamma, tumor necrosis factor (TNF)-alpha, IL-6, IL-2, IL-4 and IL-10 production in PBMC cultures from 20 patients were measured following stimulation with the M. tuberculosis-specific fusion protein ESAT-6/CFP-10. Elevated levels of IgG against ESAT-6, CFP-10 and 16 kDa antigens were detected in 0M-TB and 3M-TB patients in comparison to the HC and 6M-TB groups. Receiver operating characteristic analysis indicated sensitivity of 85, 94 and 61% and specificity of 89, 87 and 89% for serum IgG against ESAT-6, CFP-10 and 16 kDa, respectively. A predominant IgG1 response to ESAT-6 and CFP-10 was observed in 0M-TB patients, together with ESAT-6/CFP-10-specific IFN-gamma, TNF-alpha and IL-6 that were produced at lower levels in the 6M-TB group. These data indicate that a T(h)1 phenotype against early phase Mtb antigens appears to be dominant in the peripheral blood of patients with active pulmonary TB that is reduced after chemotherapy. Taken together, ESAT-6/CFP-10 cytokine tests together with detecting IgG antibodies specific to ESAT-6 and CFP-10 may be the useful TB disease biomarkers in monitoring treatment success.
机译：特异性抗体的检测可以代表诊断结核病（TB）的另外的工具。在此，在33例活性肺结核患者（0M-TB）中，测量，在33例活性肺结核患者（0M-TB）中测量血清IgG抗体的血清IgG抗体，培养滤液抗原-10（CFP-10）和16kDA分枝杆菌抗原的水平。47患者在1-3个月的治疗（3M-TB）和22例患者中完成6个月的化疗（6M-TB）。对照组由38个BCG疫苗的健康对照（HC）组成。此外，IFN-GAMMA，肿瘤坏死因子（TNF）-α，IL-6，IL-2，IL-4和IL-10在20名患者的PBMC培养物中产生，用M.结核特异性融合进行刺激测量蛋白质ESAT-6 / CFP-10。与HC和6M-TB组相比，在0M-TB和3M-TB患者中检测到对ESAT-6，CFP-10和16kDA抗原的IgG水平升高。接收器操作特征分析分别表明血清IgG对ESAT-6，CFP-10和16kDa的89,87和89％的敏感性。在0M-TB患者中观察到对ESAT-6和CFP-10的优势IgG1反应，以及在较低水平下产生的ESAT-6 / CFP-10特异性IFN-Gamma，TNF-α和IL-6。 6M-TB组。这些数据表明，针对早期相位MTB抗原的T（H）1表型似乎在化疗后减少的活性肺结核患者的外周血中显着。一起服用，ESAT-6 / CFP-10细胞因子与检测到ESAT-6和CFP-10特异的IgG抗体可以是监测治疗成功的有用的TB疾病生物标志物。

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