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首页> 外文期刊>International immunopharmacology >Renin-angiotensin system in osteoarthritis: A new potential therapy
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Renin-angiotensin system in osteoarthritis: A new potential therapy

机译：肺炎血管紧张素系统在骨关节炎：新的潜在疗法

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摘要

Osteoarthritis (OA) is one of the most common chronic joint diseases. However, the mechanism remains unclear. The traditional renin-angiotensin system (RAS) is an important system for regulating homeostasis and controlling balance. In recent years, HAS-related components have played an important role in the occurrence of OA. The purpose of this review is to summarize the research results of RAS-related components that are associated with OA. This study systematically searched e-medical databases such as PubMed, Embase, Medline, and Web of Science. The search targets included English publications describing the effects of RAS-related components in OA, including the role of renin, angiotensin-converting enzyme (ACE), Angiotensin II (Ang II), and angiotensin receptor (ATR). Additionally, this study summarizes the potential pathways for RAS-related components to intervene in OA. This study found that RAS-related components including renin, ACE, Ang II, AT1R and AT2R are involved in inflammation and chondrocyte hypertrophy in OA. RAS is involved in signaling pathways including the NF-kappa B, JNK, VEGFR/Tie-2, and the Axna2/Axna2R axis ones, which may be potential targets for the treatment of OA. Although there are few studies on RAS in the field of OA, the pathogenic effect of RAS-related components is still an important topic in OA treatment, and great progress may be made in this aspect in future studies.
机译：骨关节炎（OA）是最常见的慢性关节疾病之一。但是，该机制尚不清楚。传统的肾素 - 血管紧张素系统（RAS）是调节稳态和控制平衡的重要系统。近年来，有相关的组成部分在OA的发生中发挥了重要作用。本综述的目的是总结与OA相关的RAS相关组件的研究结果。本研究系统地搜索了电子医疗数据库，如PubMed，Embase，Medline和Scient Web。搜索目标包括描述RAS相关组分在OA中的效果的英语出版物，包括肾素，血管紧张素转换酶（ACE），血管紧张素II（ANG II）和血管紧张素受体（ATR）的作用。此外，该研究总结了与RAS相关组分的潜在途径进行干预OA。本研究发现，RAS相关组分包括肾素，ACE，ANG II，AT1R和AT2R涉及OA中的炎症和软骨细胞肥大。 RAS参与包括NF-KAPPA B，JNK，VEGFR / TIE-2和AXNA2 / AXNA2R轴线的信令途径，其可能是治疗OA的潜在靶标。虽然OA领域的RAS有很少的研究，但RAS相关组分的致病效果仍然是OA治疗中的重要课题，并且在未来的研究中可以在这方面进行巨大进展。

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  • 来源
    《International immunopharmacology》 |2019年第2019期|共7页
  • 作者

    Wu Yuangang; Lu Xiaoxi; Li Mingyang; Zeng Junfeng; Zeng Jun; Shen Bin; Zeng Yi;

  • 作者单位

    Sichuan Univ West China Hosp West China Med Sch Dept Orthopaed Surg Chengdu 610041 Sichuan;

    Sichuan Univ West China Univ Hosp 2 Dept Pediat Chengdu 610041 Sichuan Peoples R China;

    Sichuan Univ West China Hosp West China Med Sch Dept Orthopaed Surg Chengdu 610041 Sichuan;

    Sichuan Univ West China Hosp West China Med Sch Dept Orthopaed Surg Chengdu 610041 Sichuan;

    Sichuan Univ West China Hosp State Key Lab Biotherapy Lab Med Chem Chengdu 610041 Sichuan;

    Sichuan Univ West China Hosp West China Med Sch Dept Orthopaed Surg Chengdu 610041 Sichuan;

    Sichuan Univ West China Hosp West China Med Sch Dept Orthopaed Surg Chengdu 610041 Sichuan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Renin-angiotensin system; Osteoarthritis; Potential target; Treatment;

    机译：肾素 - 血管紧张素系统;骨关节炎;潜在目标;治疗;

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