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首页> 外文期刊>International immunopharmacology >Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease
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Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease

机译：人参皂苷Rg1在MPTP中的免疫调节和神经保护作用（1-甲基-4-苯基-1,2,3,6-四氢吡啶）诱导的帕金森病小鼠模型

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Ginsenoside Rg1, one of the biologically active ingredients of ginseng, has been considered to be a candidate neuroprotective drug. The objective of the study was to study the protective effects of Rg1 through the peripheral and central inflammation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model. Rg1 treatment protected TH-positive cells in the SNpc region from MPTP toxicity measured with immunofluoresence. The protein expression levels of TH in the SNpc region of MPTP-induced mice following treatment with Rg1 were higher than MPTP-induced mice which were tested with Western blot. The ratio of CD3(+)CD4(+) to CD3(+)CD8(+) T cells and CD4(+)CD25(+)Foxp3(+) regulatory T cells in the blood increased in MPTP-induced mice following treatment with Rg1 which were detected by flow cytometry analysis. Moreover, Rg1 reduced the serum concentrations of proinflammatory cytokines TNF-alpha, IFN-gamma, IL-1 beta and IL-6 which were tested with enzyme-linked immunosorbent assay (ELISA). In addition, Rg1 inhibited the activation of microglia and reduced the infiltration of CD3(+) T cells into the SNpc region which were measured by immunofluorescence. Our results indicated that Rg1 may represent a promising drug for the treatment of PD via the regulation of the peripheral and central inflammation. (C) 2015 Elsevier B.V. All rights reserved.
机译：人参皂甙RG1，人参生物活性成分之一被认为是候选神经保护药物。该研究的目的是研究RG1通过1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病（PD）小鼠模型中的外周和中枢炎症的保护作用。 RG1治疗来自用免疫荧光测量的MPTP毒性的SNPC区域中的Th阳性细胞。在用RG1处理后MPTP诱导的小鼠的SNPC区域中TH的蛋白表达水平高于MPTP诱导的小鼠，用Western印迹测试。 CD3（+）CD4（+）至CD3（+）CD8（+）T细胞和CD4（+）CD25（+）FOXP3（+）调节T细胞在血液中的血液中增加的比例增加了在处理后的MPTP诱导的小鼠中通过流式细胞术分析检测的RG1。此外，RG1降低了用酶联免疫吸附测定（ELISA）测试的促炎细胞因子TNF-α，IFN-Gamma，IL-1β和IL-6的血清浓度。另外，RG1抑制了通过免疫荧光测量的SNPC区域中CD3（+）T细胞的渗透并将CD3（+）T细胞的渗透降低。我们的结果表明，RG1可以通过调节外周和中枢炎症来代表一种用于治疗PD的有希望的药物。 （c）2015 Elsevier B.v.保留所有权利。

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