...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International immunopharmacology >Daphnetin prevents methicillin-resistant Staphylococcus aureus infection by inducing autophagic response
【24h】

Daphnetin prevents methicillin-resistant Staphylococcus aureus infection by inducing autophagic response

机译：Daphnetin通过诱导自噬反应来预防耐甲氧脲葡萄球菌感染

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) is a potentially fatal disease, featured with extensive infection, inflammation, and airway dysfunction. With the increasing emerging of drug-resistant strains, new therapeutic strategies beyond canonical antibiotic treatment are pressingly needed. Daphnetin (DAPH) is a natural coumarin derivative with anti-inflammation, anti-microorganism and anti-oxidative properties. However, the protective effect of DAPH on S. aureus-caused pneumonia and the mechanism involved are never explored. Here we show that DAPH treatment conferred substantial protection against S. aureus-induced pneumonia, characterized by the reduced inflammatory responses, the augmented bacterial clearance and the alleviated tissue damage. Our study indicates that DAPH significantly enhanced mTOR-dependent autophagic pathway, leading to the boosted microphage bactericidal activity and the suppressed inflammatory responses. Inhibition of autophagic pathway therefore largely abolished DAPH-elicited repression of inflammatory response and macrophage anti-bacterial capability. Together, we herein not only identify a novel, natural agent to combat bacterial pneumonia, but also underscore the significance of autophagic pathway in orchestrating antimicrobial and anti-inflammatory responses, which may have important implication for the treatment of the infectious diseases, particularly that caused by obstinate, antibiotic-resistant pathogens such as MRSA.
机译：由耐甲氧西林抗金黄色葡萄球菌（MRSA）引起的细菌肺炎是一个潜在的致命疾病，具有广泛的感染，炎症和气道功能障碍。随着耐药菌株的出现越来越多，迫切需要新的抗生素治疗的新治疗策略。 Daphetin（Daph）是一种具有抗炎，抗微生物和抗氧化性能的天然香豆素衍生物。然而，Daph对金黄色葡萄球菌导致肺炎和所涉及的机制的保护作用从未探索过。在这里，我们显示Daph治疗赋予了对金黄色葡萄球菌诱导的肺炎的大量保护，其特征在于炎症反应降低，增强的细菌间隙和缓解组织损伤。我们的研究表明，Daph显着增强了MTOR依赖性的自噬途径，导致提升的微杀菌活性和抑制的炎症反应。因此，对自噬途径的抑制在很大程度上废除了炎症反应和巨噬细胞抗细菌能力的抑制抑制。我们在一起，我们不仅鉴定了一种新的天然药物来打击细菌肺炎，而且强调了自噬途径在协调抗菌和抗炎反应中的意义，这可能对治疗传染病的重要意义，特别是引起的通过顽固，抗生素抗性病原体如MRSA。

著录项

  • 来源
    《International immunopharmacology》 |2019年第2019期|共9页
  • 作者

    Zhang Wei; Zhuo Shiqin; He Long; Cheng Cheng; Zhu Bo; Lu Yin; Wu Qinan; Shang Wenbin; Ge Weihong; Shi Liyun;

  • 作者单位

    Nanjing Univ Chinese Med Sch Med &

    Life Sci Nanjing 210046 Jiangsu Peoples R China;

    Zhejiang Chinese Med Univ Sch Pharmaceut Hangzhou 310053 Zhejiang Peoples R China;

    Nanjing Univ Chinese Med Sch Med &

    Life Sci Nanjing 210046 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Sch Med &

    Life Sci Nanjing 210046 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Sch Med &

    Life Sci Nanjing 210046 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Sch Pharm Jiangsu Key Lab Pharmacol &

    Safety Evaluat Chines Nanjing;

    Collaborat Innovat Ctr Chinese Med Resources Indu Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Sch Clin Med 1 Nanjing 210023 Jiangsu Peoples R China;

    Zhejiang Chinese Med Univ Sch Pharmaceut Hangzhou 310053 Zhejiang Peoples R China;

    Nanjing Univ Chinese Med Sch Med &

    Life Sci Nanjing 210046 Jiangsu Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Staphylococcus aureus; Pneumonia; Daphnetin; Autophagy;

    机译：金黄色葡萄球菌;肺炎;Daphetin;自噬;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号