A randomized controlled dose-escalation study of SSS07, a humanized rabbit anti-human TNF alpha antibody, in healthy Chinese adults

Wang Qi; Xie Xinyao; Su Feng; Wang Jiaxue; Chen Shi; Wang Qian; Jiang Daoli; Wang Yitong; Zhang Tan; Liu Chang; Han Min; Tao Tao; Wu Quanrui; Xi Nana; Li Zhanguo; Song Haifeng; Fang Yi

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A randomized controlled dose-escalation study of SSS07, a humanized rabbit anti-human TNF alpha antibody, in healthy Chinese adults

机译：SSS07的随机对照剂量升级研究，人源兔抗人TNFα抗体，健康的中国成人

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摘要

Aims: SSS07 is a rabbit derived humanized anti-human TNF-alpha antibody. This study aimed to explore the pharmacokinetics, safety, and immunogenicity of SSS07 when administrated subcutaneously in healthy adults.

机译：目的：SSS07是兔衍生的抗人源化抗人类TNF-α抗体。本研究旨在探讨SSS07的药代动力学，安全性和免疫原性，当时在健康成年人中映射时。

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来源
《International immunopharmacology》 |2019年第2019期|共7页
作者
Wang Qi; Xie Xinyao; Su Feng; Wang Jiaxue; Chen Shi; Wang Qian; Jiang Daoli; Wang Yitong; Zhang Tan; Liu Chang; Han Min; Tao Tao; Wu Quanrui; Xi Nana; Li Zhanguo; Song Haifeng; Fang Yi;
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作者单位

Peking Univ Dept Pharm Peoples Hosp Beijing Peoples R China;

United Power Pharma Tech Co Beijing Peoples R China;

Peking Univ Dept Pharm Peoples Hosp Beijing Peoples R China;

Peking Univ Dept Pharm Peoples Hosp Beijing Peoples R China;

Peking Univ Dept Rheumatol &

Immunol Peoples Hosp Beijing Peoples R China;

Peking Univ Dept Pharm Peoples Hosp Beijing Peoples R China;

Affiliated Hosp Xuzhou Med Univ Dept Pharm Xuzhou Jiangsu Peoples R China;

Aix Marseille Univ 27 Bd Jean Moulin F-13385 Marseille 05 France;

Peking Univ Dept Pharm Peoples Hosp Beijing Peoples R China;

Guangzhou Med Univ Qingyuan Peoples Hosp Affiliated Hosp 6 Qingyuan Peoples R China;

United Power Pharma Tech Co Beijing Peoples R China;

Shenyang Sunshine Pharmaceut Co Ltd Shenyang Liaoning Peoples R China;

Shenyang Sunshine Pharmaceut Co Ltd Shenyang Liaoning Peoples R China;

United Power Pharma Tech Co Beijing Peoples R China;

Peking Univ Dept Rheumatol &

Immunol Peoples Hosp Beijing Peoples R China;

Beijing Inst Radiat Med Dept Pharmacol &

Toxicol Beijing Peoples R China;

Peking Univ Dept Pharm Peoples Hosp Beijing Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
SSS07; Antibodies; TNF-alpha; PK; Immunogenicity;

机译：SSS07;抗体;TNF-α;PK;免疫原性;

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1. A randomized controlled dose-escalation study of SSS07, a humanized rabbit anti-human TNF alpha antibody, in healthy Chinese adults [J] . Wang Qi, Xie Xinyao, Su Feng, International immunopharmacology . 2019,第期

机译：SSS07的随机对照剂量升级研究，人源兔抗人TNFα抗体，健康的中国成人
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A randomized controlled dose-escalation study of SSS07, a humanized rabbit anti-human TNF alpha antibody, in healthy Chinese adults

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