...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International immunopharmacology >Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation
【24h】

Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation

机译：Guggulsterone通过Erk和JNK激活抑制Cerulein诱导的急性胰腺炎

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Guggulsterone (GS), a plant steroid and a compound found at high levels in Commiphora myrrha, exhibits anti-inflammatory, anti-cancer, and cholesterol-lowering effects. However, the potential of GS to ameliorate acute pancreatitis (AP) is unknown. The aim of this study was to evaluate the effects of GS on cerulein-induced AP. AP was induced by intraperitoneally injecting supramaximal concentrations of the stable cholecystoldnin analog cerulein (50 mu g/kg) hourly for 6 h. In the GS-treated group, GS was administered intraperitoneally (10, 25, or 50 mg/kg) 1 h before the first cerulein injection. Mice were sacrificed 6 h after the final cerulein injection. Blood samples were collected to measure serum lipase levels and evaluate cytokine production. The pancreas and lung were rapidly removed for morphologic and histological examinations, flow cytometry analysis, myeloperoxidase (MPO) assay, and real-time reverse transcription-polymerase chain reaction analysis. Pretreatment with GS attenuated cerulein-induced histological damage, reduced pancreas weight/body weight ratio, decreased serum lipase levels, inhibited infiltrations of macrophages and neutrophils, and suppressed cytokine production. Additionally, GS treatment suppressed the activation of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) in the pancreas in cerulein-induced pancreatitis. In conclusion, our results suggest that GS attenuates AP via deactivation of ERK and JNK. (c) 2015 Elsevier B.V. All rights reserved.
机译：Guggulsterone（GS），植物类固醇和在Conmibhora myrrha的高水平上发现的化合物，具有抗炎，抗癌和降低胆固醇的效果。然而，GS对改善急性胰腺炎（AP）的潜力是未知的。本研究的目的是评估GS对Cerulein诱导的AP的影响。通过腹膜内注射稳定的胆囊杆菌稳定性浓度（50μg/ kg）每小时6小时的稳定胆囊杆菌模拟系列（50μg/ kg）诱导。在GS处理的组中，在第一个CERULEIN注射之前，在腹膜内（10,25，或50mg / kg）给药GS。在最后的Cerulein注射后，在6小时内处死了小鼠。收集血液样品以测量血清脂肪酶水平并评估细胞因子产生。胰腺和肺被迅速除去形态学和组织学检查，流式细胞术分析，髓过氧化物酶（MPO）测定和实时逆转录聚合酶链反应分析。对Gs减弱的组织学损伤的预处理，减少胰腺重量/体重比，降低血清脂肪酶水平，抑制巨噬细胞和中性粒细胞的渗透，并抑制细胞因子产生。另外，GS治疗抑制了Cerulein诱导的胰腺炎胰腺细胞外信号调节蛋白激酶（ERK）和C-JUN N-末端激酶（JNK）的激活。总之，我们的结果表明，GS通过反应激活ERK和JNK衰减AP。 （c）2015 Elsevier B.v.保留所有权利。

著录项

  • 来源
    《International immunopharmacology》 |2015年第1期|共9页
  • 作者

    Kim Dong-Goo; Bae Gi-Sang; Choi Sun-Bok; Jo Il-Joo; Shin Joon-Yeon; Lee Sung-Kon; Kim Myoung-Jin; Kim Min-Jun; Jeong Hyun-Woo; Choi Chang-Min; Seo Seung-Hee; Choo Gab-Chul; Seo Sang-Wan; Song Ho-Joon; Park Sung-Joo;

  • 作者单位

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Hanbang Body Fluid Res Ctr Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Dongshin Univ Dept Pathol Coll Korean Med Naju 520714 Jeonnam South Korea;

    Wonkwang Univ Dept Obstet &

    Gynecol Coll Oriental Med Iksan 570749 Jeonbuk South Korea;

    Dongshin Univ Dept Cosmetol Naju 520714 Jeonnam South Korea;

    Gyeongnam Natl Univ Sci &

    Technol Dept Forest Resources Jinju 660758 Gyeongnam South Korea;

    Honam Univ Dept Oriental Med Ind Gwangju 506714 South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

    Wonkwang Univ Profess Grad Sch Oriental Med Plus Team BK21 Iksan 540749 Jeonbuk South Korea;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Acute pancreatitis (AP); Cytokine; (E)-Guggulsterone (GS); Macrophage; Mitogen activated protein kinase (MAPK); Neutrophil;

    机译：急性胰腺炎（AP）;细胞因子;（e）-guggultstone（gs）;巨噬细胞;丝噬细胞活化蛋白激酶（MAPK）;中性粒细胞;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号