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首页> 外文期刊>International immunopharmacology >Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2
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Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2

机译：通过下调MDM2，致动态致衰减TSLP诱导的肥大细胞增殖

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Acteoside (verbascoside) is extensively distributed in Abeliophyllum distichum and has antimicrobial and anti-inflammatory properties. Thymic stromal lymphopoietin (TSLP) has a pivotal function in the pathogeneses of inflammatory diseases through increasing the mast cell proliferation via the activation of murine double minute 2 (MDM2). Here, we investigate whether acteoside attenuates the MDM2 expression in a TSLP-stimulated human mast cell line (HMC-1 cells). In these cells, TSLP induced the up-regulation of MDM2, and the down-regulation of p53; however, in the TSLP-stimulated HMC-1 cells, the acteoside down-regulated the MDM2 and up-regulated the p53. Increases in the phosphorylation of the single transducer and activation of transcription 6 and 5 via TSLP are decreased by acteoside. The interleukin (IL)-13 (a mast cell growth factor), IL-6, tumor necrosis factor-alpha, and IL-1 beta, levels are significantly reduced by the acteoside in the TSLP-stimulated HMC-1 cells, and the acteoside significantly induces the activation of caspase-3, the cleavage of poly-ADP-ribose polymerase, and the reduction of the procaspase-3 and Bcl2. Furthermore, the mRNA expressions of the TSLP receptor and IL-7 receptor that increase due to TSLP are reduced by the acteoside. In conclusion, these results indicate that acteoside is a specific regulator of MDM2 activation in TSLP-stimulated mast cells, which indicates its potential use for the treatment of mast cell-mediated inflammatory diseases. (C) 2015 Elsevier B.V. All rights reserved.
机译：致动态（血管内酯）广泛分布在亚伯希曲线畸变中，具有抗微生物和抗炎特性。通过通过激活鼠双分钟2（MDM2），通过增加肥大细胞增殖，在炎症性疾病的病原体中具有枢轴功能。在这里，我们研究了雌激素是否衰减在TSLP刺激的人肥大细胞系（HMC-1细胞）中的MDM2表达。在这些细胞中，TSLP诱导MDM2的上调，以及P53的下调;然而，在TSLP刺激的HMC-1细胞中，雌激素下调MDM2并上调P53。通过致动氢化物降低单个换能器的磷酸化和通过TSLP的转录6和5的激活增加。白细胞介素（IL）-13（肥大细胞生长因子），IL-6，肿瘤坏死因子 - α和IL-1β，COSLP刺激的HMC-1细胞中的雌激素显着降低，水平显着减少致动岩显着诱导Caspase-3的活化，聚-Adp-核糖聚合酶的切割，以及降低Procaspase-3和Bcl2。此外，CATEOSIDE减少了TSLP受体和IL-7受体的MRNA表达，其由于TSLP增加而增加。总之，这些结果表明，致动物是TSLP刺激的肥大细胞中MDM2活化的特定调节剂，这表明其潜在使用用于治疗肥大细胞介导的炎性疾病。 （c）2015 Elsevier B.v.保留所有权利。

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