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首页> 外文期刊>International immunopharmacology >Vaccination with FasL-/TCL plus MHSP65 induces improved anti-lung cancer immunity in mice
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Vaccination with FasL-/TCL plus MHSP65 induces improved anti-lung cancer immunity in mice

机译：使用Fasl-/ Tcl Plus MHSP65疫苗接种诱导小鼠的改善的抗肺癌免疫力

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In a previous study, we constructed a MHSP65-TCL anti-lung cancer vaccine with Lewis lung carcinoma TCL plus MHSP65, and illustrated its anti-lung cancer effect through specific and nonspecific anti-tumor immunity. However, TCL contains some immunoinhibit components such as FasL. If this component can be eliminated from TCL, the anti-tumor immunity of MHSP65-TCL constructed with TCL should be improved. In the present study, we knocked down FasL from Lewis lung carcinoma cells and prepared MHSP65-(FasL-/TCL) with this cell line's TCL. After further investigation, MHSP65-(FasL-/TCL) exhibited a better ability to reduce splenocytes apoptosis, promote its activation and secretion of secretingTNF-beta, IL-2 compared with MHSP65-(FasL +/TCL). Accordingly, specific and nonspecific antitumor immunity induced by MHSP65-(FasL-/TCL) is stronger than that of MHSP65-(FasL +/TCL). In vivo, MHSP65-(FasL-/TCL) immunization can prolong survival of Lewis lung carcinoma bearing mice. Thus, we report that the anti-lung cancer effect of MHSP65-TCL can be improved by removal of FasL from the TCL. It provides a new route to construct MHSP65-TCL and other antitumor vaccines based on TCL.
机译：在先前的研究中，我们通过特异性和非特异性抗肿瘤免疫力构建了具有Lewis肺癌TCL Plus MHSP65的MHSP65-TCL抗肺癌疫苗。然而，TCL含有一些免疫抑制组件，例如FasL。如果该组分可以从TCL中消除，则应改善用TCl构建的MHSP65-TCl的抗肿瘤免疫力。在本研究中，我们从Lewis肺癌细胞中击倒了FasL，并用这种细胞系的TCL制备MHSP65-（Fasl-/ Tcl）。在进一步调查之后，MHSP65-（FASL-/ TCL）表现出更好的减少脾细胞凋亡的能力，促进其与MHSP65-（Fasl + / TCl）相比分泌的分泌细胞β的激活和分泌。因此，MHSP65-（FASL-/ TCL）诱导的特异性和非特异性抗肿瘤免疫比MHSP65-（FASL + / TCL）强。体内，MHSP65-（Fasl-/ Tcl）免疫可以延长刘易斯肺癌轴承小鼠的存活。因此，我们报告说，通过从TCl中除去FasL可以提高MHSP65-TCl的抗肺癌作用。它提供了基于TCL构建MHSP65-TCL和其他抗肿瘤疫苗的新途径。

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