...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International immunopharmacology >Exogenous ghrelin ameliorates acute lung injury by modulating the nuclear factor kappa B inhibitor kinase/nuclear factor kappa B inhibitor/nuclear factor kappa B pathway after hemorrhagic shock
【24h】

Exogenous ghrelin ameliorates acute lung injury by modulating the nuclear factor kappa B inhibitor kinase/nuclear factor kappa B inhibitor/nuclear factor kappa B pathway after hemorrhagic shock

机译：外源性Ghrelin通过调节核因子Kappa B抑制剂激酶/核因子Kappa B抑制剂/核因子Kappa B途径来改善急性肺损伤

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous studies have shown that ghrelin, a peptide produced in the stomach, attenuates acute lung injury (ALI) in various animal models, and that some of these effects are associated with inhibition of the nuclear factor kappa B signaling pathway. This study investigated whether ghrelin exerts beneficial effects on hemorrhagic shock (HS)-induced ALI by modulating nuclear factor kappa B inhibitor kinase/nuclear factor kappa B inhibitor/nuclear factor kappa B (IKK/I kappa B alpha/NF-kappa B) pathway activity. HS was induced in male SD rats by withdrawing blood to a mean arterial pressure (MAP) of 40 mm Hg for 1 h; rats then received ghrelin (10 nmol/kg) or vehicle intravenously and were resuscitated with the shed blood and an equal volume of Ringer lactate solution followed by observation for 2 h. After resuscitation, samples were collected and analyzed for lung histopathology, wet to dry weight ratio (W/D), bronchoalveolar lavage fluid (BALF) protein, neutrophil infiltration, plasma inflammatory cytokines (TNF-alpha and IL-6), and cytoplasmic phosphorylated IKK beta, I kappa B alpha, phosphorylated I kappa B alpha and nuclear NF-kappa B expression. Compared to those in the two sham groups, lung injury, W/D, BALF protein, neutrophil infiltration, plasma TNF-alpha and IL-6 levels, and IKK/I kappa B alpha/NF-kappa B pathway activation were significantly increased in HS rats. After ghrelin administration, all parameters analyzed were decreased compared to those without ghrelin in HS rats. Moreover, ghrelin alleviated the decreased MAP after resuscitation compared to that in HS rats. Exogenous ghrelin attenuates the inflammatory response and acute lung injury after HS. These beneficial effects appear to be mediated through inhibition of IKK/I kappa B alpha/NF-kappa B signaling.
机译：以前的研究表明，胃中产生的肽的Ghrelin衰减各种动物模型中的急性肺损伤（ALI），并且一些这些效果与核因子Kappa B信号通路的抑制相关。本研究研究了GHRELIN是否对核因子Kappa B抑制剂激酶/核因子Kappa抑制剂/核因子Kappa B抑制剂/核因子Kappa B（IKK / I KappaBα/ NF-Kappa）途径施加对出血性休克（HS）的有益作用活动。通过将血液吸入40mm Hg的平均动脉压（Map），在雄性SD大鼠中诱导HS。然后将大鼠静脉内接受Ghrelin（10nmol / kg）或载体，并用血液血液和相等体积的林氏乳酸溶液复苏，然后观察2小时。复苏后，收集样品并分析肺组织病理学，润湿至干重比（W / D），支气管肺泡灌洗液（BALF）蛋白，中性粒细胞浸润，血浆炎症细胞因子（TNF-α和IL-6），以及细胞质磷酸化IKK Beta，I KappaBα，磷酸化的I KappaBα和核NF-Kappa B表达。与两组中的那些，肺损伤，W / D，BALF蛋白，中性粒细胞浸润，血浆TNF-α和IL-6水平相比，IKK / I KappaBα/ NF-Kappa B途径激活显着增加HS大鼠。在GHRELIN管理后，与HS大鼠中没有GHRELIN的人相比，分析的所有参数都减少。此外，与HS大鼠相比，Ghrelin减轻了复苏后的降低的地图。外源Ghrelin衰减HS后炎症反应和急性肺损伤。这些有益的效果似乎通过IKK / I Kappa Bα/ NF-Kappa B信号的抑制来介导。

著录项

  • 来源
    《International immunopharmacology》 |2019年第2019期|共8页
  • 作者

    Zhang Li-Na; Gong Wei-Dong; Luo Juan; Yu Yong-Jing; Qi Si-Hua; Yue Zi-Yong;

  • 作者单位

    Harbin Med Univ Dept Anesthesiol Affiliated Hosp 4 37 Yiyuan St Harbin 150001 Heilongjiang;

    Harbin Med Univ Dept Anesthesiol Affiliated Hosp 2 246 Xuefu Rd Harbin 150001 Heilongjiang;

    Harbin Med Univ Dept Anesthesiol Affiliated Hosp 2 246 Xuefu Rd Harbin 150001 Heilongjiang;

    Harbin Med Univ Dept Anesthesiol Affiliated Hosp 2 246 Xuefu Rd Harbin 150001 Heilongjiang;

    Harbin Med Univ Dept Anesthesiol Affiliated Hosp 4 37 Yiyuan St Harbin 150001 Heilongjiang;

    Harbin Med Univ Dept Anesthesiol Affiliated Hosp 2 246 Xuefu Rd Harbin 150001 Heilongjiang;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Acute lung injury; Ghrelin; Hemorrhagic shock; Nuclear factor kappa B pathway;

    机译：急性肺损伤;Ghrelin;出血休克;核因子Kappa B途径;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号