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首页> 外文期刊>International immunopharmacology >Oridonin inhibits IL-1 beta-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-gamma
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Oridonin inhibits IL-1 beta-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-gamma

机译：奥黛隆抑制人骨关节炎软骨细胞中的IL-1β诱导的炎症通过激活PPAR-Gamma

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摘要

Osteoarthritis (OA), a progressive disease of the joints, affects millions of people worldwide. In the present study, we investigated the effects of oridonin, a diterpenoid isolated from Rabdosia rubescens, on IL-1 beta-induced inflammation using human osteoarthritis chondrocytes. The results showed that oridonin significantly suppressed IL-1 beta-induced MMP1, MMP3, and MMP13 production. IL-1 beta-induced NO and PGE(2) production, as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were also attenuated by oridonin. Western blot analysis demonstrated IL-1 beta-induced NF-kappa B activation was reduced by oridonin. Furthermore, the expression of PPAR-gamma was increased by oridonin in a concentration-dependent manner. PPAR-gamma antagonist could reverse the anti-inflammatory activity of oridonin. The results suggested that oridonin could be a candidate agent for the treatment of OA.
机译：骨关节炎（OA）是联合的渐进性疾病，影响全球数百万人。 在本研究中，我们研究了使用人骨关节细胞的IL-1β诱导的炎症，研究了oridonin的影响。 结果表明，奥里丹林明显抑制了IL-1β诱导的MMP1，MMP3和MMP13生产。 IL-1β诱导的NO和PGE（2）制备以及诱导型一氧化氮合酶（InOS）和环氧氧酶-2（COX-2）表达也衰减。 Western印迹分析证明IL-1β诱导的NF-Kappa B激活由奥利替甙降低。 此外，奥利替素以浓度依赖性方式增加PPAR-γ的表达。 PPAR-Gamma拮抗剂可以逆转奥里诺蛋白的抗炎活性。 结果表明，厄里多恩可以是治疗OA的候选剂。

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  • 来源
    《International immunopharmacology》 |2019年第2019期|共7页
  • 作者

    Jia Tao; Cai Mengmeng; Ma Xu; Li Ming; Qiao Jiutao; Chen Tianxin;

  • 作者单位

    Harbin Med Univ Affiliated Hosp 2 Dept Orthopaed Surg Harbin 150086 Heilongjiang Peoples R;

    Harbin Med Univ Affiliated Hosp 2 Dept Orthopaed Surg Harbin 150086 Heilongjiang Peoples R;

    Harbin Med Univ Affiliated Hosp 2 Dept Orthopaed Surg Harbin 150086 Heilongjiang Peoples R;

    Harbin Med Univ Affiliated Hosp 2 Dept Orthopaed Surg Harbin 150086 Heilongjiang Peoples R;

    Harbin Med Univ Affiliated Hosp 2 Dept Orthopaed Surg Harbin 150086 Heilongjiang Peoples R;

    Harbin Med Univ Affiliated Hosp 2 Dept Orthopaed Surg Harbin 150086 Heilongjiang Peoples R;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Oridonin; Chondrocytes; IL-1 beta; NF-kappa B;

    机译：Oridin;软骨细胞;IL-1 beta;NF-Kappa B.;

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