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首页> 外文期刊>International immunopharmacology >MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis
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MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis

机译：Mast3调节类风湿性关节炎中成纤维细胞样Synociytes的炎症反应和增殖

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摘要

Via promoting synovitis, pannus growth and cartilage/bone destruction, fibroblast-like synovial cells (FLSs) play a significant role in the pathogenesis of rheumatoid arthritis (RA). In our study, rats were induced with complete freunds adjuvant (CFA) to be animal models for studying the RA pathogenesis. Microtubule-associated Serine/Threonine-protein kinase 3 (MAST3) has been documented to play a critical role in regulating the immune response of IBD (Inflammatory bowel disease) and involved in the process of cytoskeleton organization, intracellular signal transduction and peptidyl-serine phosphorylation, but its role in the progression of RA remains unknown and is warranted for investigation. So, we tried our best to investigate the mechanism and signaling pathway of MAST3 in RA progression. In the synovial tissue and FLSs of AA rats, we have found that MAST3 was significantly up-regulated than normal. Furthermore, MAST3 overexpression could promote proliferation and inflammatory response of FLSs. In the aspect of mechanism, we discovered that the expression of MAST3 might involve in NF-築 signaling pathway in RA. On the whole, our results suggested that MAST3 might promote the proliferation and inflammation of FLSs by regulating NF-築 signaling pathway.
机译：通过促进滑膜炎，Pannus生长和软骨/骨破坏，成纤维细胞样滑膜细胞（FLS）在类风湿性关节炎（RA）的发病机制中起着重要作用。在我们的研究中，用完整的弗氏佐剂（CFA）诱导大鼠作为研究RA发病机制的动物模型。已经记录了微管相关的丝氨酸/苏氨酸 - 蛋白激酶3（MAST3），以在调节IBD（炎症肠疾病）的免疫应答中起着关键作用，并参与细胞骨架组织，细胞内信号转导和肽基 - 丝氨酸磷酸化，但它在RA的进展中的作用仍然不为人知，并有权进行调查。因此，我们尽力调查Ra进展中Mast3的机制和信号通路。在AA大鼠的滑膜组织和霉菌中，我们发现乳腺3显着上调而不是正常。此外，MAST3过表达可以促进FLSS的增殖和炎症反应。在机制的方面，我们发现MAST3的表达可能涉及RA中的NF-筑信号通路。总的来说，我们的结果表明，MAST3可以通过调节NF-信号通路来促进霉菌的增殖和炎症。

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