...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Bleeding profiles and effects on the endometrium for women using a novel combination of transdermal oestradiol and natural progesterone cream as part of a continuous combined hormone replacement regime.
【24h】

Bleeding profiles and effects on the endometrium for women using a novel combination of transdermal oestradiol and natural progesterone cream as part of a continuous combined hormone replacement regime.

机译：使用经皮雌二醇和天然孕激素乳膏的新型组合作为连续联合激素替代方案的一部分，对女性的出血情况及其对子宫内膜的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective Many women are seeking alternatives to conventional forms of hormone replacement. This study evaluates the endometrial effects of natural progesterone cream used in conjunction with transdermal oestradiol. Design Open plan study conducted over 48 weeks. Setting Tertiary referral London teaching hospital. Population Women at least two years postmenopausal. Methods Women were recruited nationally. They applied 40 mg transdermal natural progesterone cream and 1 mg transdermal oestradiol daily. Main outcome measures Endometrial histology, assessed by pipelle endometrial biopsy, ultrasound assessment of endometrial thickness and bleeding diaries. Results Fifty-four women were recruited of which 41 completed the study. Mean age was 57.4 years. Thirty-two percent of women had evidence of inadequate endometrial opposition (proliferative or hyperplastic) at the end of 48 weeks. At baseline, women had a mean endometrial thickness of 3.3 mm, which had significantly thickened to a mean of 5.3 mm by 24 weeks (P < 0.001). By 48 weeks, there was significantly greater increase in endometrial thickness from baseline in those women who displayed inadequate endometrial opposition, compared with those women who had adequate endometrial opposition (P= 0.004). At 24 weeks, 48% of women had remained entirely amenorrhoeic. By the end of the study, 35% of women had been entirely amenorrhoeic and 50% had had either no bleeding or spotting alone. The number of bleeding episodes did not reduce with time. Conclusions The dose of natural progesterone cream in this study was insufficient to fully attenuate the mitogenic effect of oestrogen on the endometrium. We would not recommend this combination of hormones to be used by postmenopausal women.
机译：目的许多女性正在寻求替代传统形式的激素替代品。这项研究评估了天然孕激素乳膏与经皮雌二醇一起使用对子宫内膜的影响。设计开放计划研究进行了48周。设置三级转诊伦敦教学医院。人口绝经后至少两年的妇女。方法妇女是全国招募的。他们每天使用40 mg透皮天然孕酮乳膏和1 mg透皮雌二醇。主要预后指标子宫内膜组织学，通过Pipelle子宫内膜活检，超声评估子宫内膜厚度和出血日记进行评估。结果招募了54名女性，其中41名完成了研究。平均年龄为57.4岁。 48周结束时，有32％的女性有子宫内膜对立不足的证据（增生或增生）。在基线时，女性的子宫内膜平均厚度为3.3毫米，到24周时，子宫内膜的平均厚度明显增至5.3毫米（P <0.001）。到48周时，与子宫内膜对位不足的女性相比，子宫内膜对位不足的女性的子宫内膜厚度较基线明显增加（P = 0.004）。在第24周时，有48％的女性完全闭经。到研究结束时，35％的妇女完全闭经，50％的妇女没有出血或仅出现斑点。出血发作的次数并未随时间减少。结论：本研究中的天然孕激素乳膏剂量不足以完全减弱雌激素对子宫内膜的促有丝分裂作用。我们不建议绝经后妇女使用这种激素组合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号