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首页> 外文期刊>International journal of applied mechanics >In Vitro Performance of an Investigational Vibrating-Membrane Nebulizer with Surfactant under Simulated, Non-Invasive Neonatal Ventilation Conditions: Influence of Continuous Positive Airway Pressure Interface and Nebulizer Positioning on the Lung Dose
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In Vitro Performance of an Investigational Vibrating-Membrane Nebulizer with Surfactant under Simulated, Non-Invasive Neonatal Ventilation Conditions: Influence of Continuous Positive Airway Pressure Interface and Nebulizer Positioning on the Lung Dose

机译：在模拟，非侵入性新生儿通风条件下具有表面活性剂的研究振动膜雾化器的体外性能：连续正气道压力界面和雾化器定位对肺剂量的影响

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Non-invasive delivery of nebulized surfactant has been a long-pursued goal in neonatology. Our aim was to evaluate the performance of an investigational vibrating-membrane nebulizer in a realistic non-invasive neonatal ventilation circuit with different configurations. Surfactant (aerosols were generated with a nebulizer in a set-up composed of a continuous positive airway pressure (CPAP) generator with a humidifier, a cast of the upper airway of a preterm infant (PrINT), and a breath simulator with a neonatal breathing pattern. The lung dose (LD), defined as the amount of surfactant collected in a filter placed at the distal end of the PrINT cast, was determined after placing the nebulizer at different locations of the circuit and using either infant nasal mask or nasal prongs as CPAP interfaces. The LD after delivering a range of nominal surfactant doses (100-600 mg/kg) was also investigated. Surfactant aerosol particle size distribution was determined by laser diffraction. Irrespective of the CPAP interface used, about 14% of the nominal dose (200 mg/kg) reached the LD filter. However, placing the nebulizer between the Y-piece and the CPAP interface significantly increased the LD compared with placing it 7 cm before the Y-piece, in the inspiratory limb. (14% +/- 2.8 vs. 2.3% +/- 0.8, nominal dose of 200 mg/kg). The customized eFlow Neos showed a constant aerosol generation rate and a mass median diameter of 2.7 mu m after delivering high surfactant doses (600 mg/kg). The customized eFlow Neos nebulizer showed a constant performance even after nebulizing high doses of undiluted surfactant. Placing the nebulizer between the Y-piece and the CPAP interface achieves the highest LD under non-invasive ventilation conditions.
机译：雾化表面活性剂的非侵入性递送是新生儿学的长期目标。我们的目的是评估采用不同配置的现实非侵入性新生儿通风电路中的调查振动膜雾化器的性能。表面活性剂（气溶胶用雾化器在设定中由带有加湿器的连续正气道压力（CPAP）发电机组成的设定，喷雾剂上的上气道（打印）的铸造，以及带有新生儿呼吸的呼吸模拟器在将雾化器放置在电路的不同位置并使用婴儿鼻掩模或鼻叉之后，测定定义为放置在印刷铸件的远端处的过滤器中收集的表面活性剂量的肺剂量（LD）。作为CPAP接口。还研究了递送一系列标称表面活性剂剂量（100-600mg / kg）后的LD。通过激光衍射测定表面活性剂气溶胶粒度分布。无论使用的CPAP界面，占名义的约14％剂量（200mg / kg）达到LD过滤器。但是，与在吸气中将其放置7厘米，将雾化器放置在Y片和CPAP界面之间显着增加LD肢体。 （14％+/- 2.8与2.3％+/- 0.8，标称剂量为200 mg / kg）。定制的eflow neos显示出高表面活性剂剂量（600mg / kg）后恒定的气溶胶产生速率和2.7μm的质量中值直径。即使在雾化高剂量未稀释的表面活性剂之后，定制的eflow neos雾化器也表现出恒定的性能。将雾化器放置在Y片之间，CPAP接口在非侵入式通风条件下实现最高的LD。

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