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首页> 外文期刊>Advanced Powder Technology: The internation Journal of the Society of Powder Technology, Japan >Breakage, temperature dependency and contamination of Lactose during ball milling in ethanol
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Breakage, temperature dependency and contamination of Lactose during ball milling in ethanol

机译：乙醇球磨过程中乳糖的破损，温度依赖性和污染

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摘要

Wet stirred media milling is an established method for the production of drug nanoparticles which are increasing the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). While the processability of various organic materials has been proved in aqueous suspensions, this work focuses on the milling of the organic substance Lactose in ethanol. The aim of this study was the comparison of these results with the former studies in stirred media mills with organic materials in water as well as the analysation of recrystallization processes induced by increasing suspension temperature. Regarding the milling performance different grinding media materials as well as sizes, stirrer tip speeds and the solids contents of the suspension were varied. Furthermore the amount of generated product contamination was measured and a correlation to the process parameters and the used grinding beads was analysed. A convincing valuation of the milling results is only possible if there are no agglomeration effects in the suspensions. Therefore, at the beginning a stabiliser screening with different ionic and non-ionic additives was performed in a planetary ball mill. This showed an effect of the process temperature on the recrystallization behaviour of the particles and, thus, the final product fineness and particle shapes what was furthermore confirmed by milling the Lactose under controlled conditions in a stirred media mill. (C) 2016 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.
机译：湿法搅拌介质研磨是用于生产药物纳米颗粒的成熟方法，该药物纳米颗粒增加了水溶性差的活性药物成分（API）的生物利用度。尽管在水悬浮液中已证明了各种有机材料的可加工性，但这项工作的重点是在乙醇中研磨有机物质乳糖。这项研究的目的是将这些结果与以前在搅拌机中使用有机材料在水中的研究结果进行比较，以及对由于悬浮液温度升高而引起的重结晶过程进行分析。关于研磨性能，不同的研磨介质材料以及尺寸，搅拌器尖端速度和悬浮液的固体含量都不同。此外，测量了产生的产物污染的量，并且分析了与工艺参数和所使用的研磨珠的相关性。只有在悬浮液中没有附聚效果的情况下，才能对研磨结果进行令人信服的评估。因此，开始时在行星式球磨机中用不同的离子和非离子添加剂进行稳定剂筛选。这显示了加工温度对颗粒的重结晶行为的影响，因此，最终产物的细度和颗粒形状的影响还通过在受控的介质研磨机中在受控条件下研磨乳糖来证实。 （C）2016日本粉末技术学会。由Elsevier B.V.和日本粉末技术学会出版。版权所有。

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