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首页> 外文期刊>International journal of colorectal disease. >Colonic methanogenesis in vivo and in vitro and fecal pH after resection of colorectal cancer and in healthy intact colon
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Colonic methanogenesis in vivo and in vitro and fecal pH after resection of colorectal cancer and in healthy intact colon

机译：切除结肠直肠癌和健康完整结肠后体内和体外和粪便pH的结肠癌和粪便。

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Purpose: We compared colonic methanogenesis in vivo and in vitro as well as fecal pH in healthy subjects and in patients with resected colorectal cancer thus without the possible confounding effects of the tumor. Methods: A total of 144 subjects, 96 with resected colorectal cancer (of whom, 48 were with metastatic disease), 48 healthy subjects with intact colon, were analyzed for breath methane, fecal methanogenesis in vitro and fecal pH. In addition, the association between methanogenesis and pH with cancer site, operation technique and abdominal discomfort was investigated. Results: In vivo and in vitro methane measurements were in agreement. The percentage of breath methane excretors and fecal pH did not significantly differ in participants resected for colorectal cancer, either with (46%, 6.76) or without (46%, 6.77) metastatic disease, from healthy participants (40%, 6.80). Breath methane excretors had higher fecal pH than nonexcretors (7.05 versus 6.57, P<0.001) and less abdominal discomfort (30% versus 54%, P=0.016). Among patients with resected right-sided cancer (n=15), there were less breath methane excretors (20%) than among those with resected left-sided cancer (51%, n=81, P=0.029) as well as lower fecal pH than among those with resected left-sided cancer (6.27 versus 6.86, P=0.002) and among healthy subjects (6.80, P=0.010). Conclusions Patients with resected colorectal cancer were as frequently methane producers as healthy subjects with intact colon, and there was no difference in their fecal pH. Low methanogenesis was found in patients with abdominal discomfort and is a possible characteristic, along with low fecal pH, to right-sided colorectal cancer.
机译：目的：我们在体内和体外比较结肠癌和体外，以及在健康受试者中的粪便pH和切除结肠直肠癌的患者，因此没有可能的肿瘤可能的混淆作用。方法：共有144名受试者，96名患有切除结肠直肠癌（其中48例，48例，具有转移性疾病），分析了48种具有完整结肠的健康受试者，用于呼吸甲烷，粪便甲烷化体体外和粪便pH值。此外，还研究了甲烷化与pH与癌症部位，操作技术和腹部不适之间的关联。结果：体内和体外甲烷测量有一致。呼吸甲烷排泄物和粪便pH的百分比在切除结肠直肠癌的参与者中没有显着不同，其中（46％，6.76）或没有（46％，6.77）转移性疾病，来自健康参与者（40％，6.80）。呼吸甲烷排泄物比没有动词患者更高的粪便pH（7.05与6.57，P <0.001）和较少的腹部不适（30％对54％，P = 0.016）。在切除右侧癌症（n = 15）的患者中，少量呼吸甲烷排泄物（20％）比被切除的左侧癌症（51％，n = 81，p = 0.029）以及较低的粪便pH比在切除左侧癌症（6.27对6.86，P = 0.002）和健康受试者（6.80，P = 0.010）中的pH值。结论切除结肠直肠癌的患者常常作为具有完整结肠的健康受试者的甲烷生产商，其粪便pH没有差异。在腹部不适的患者中发现了低甲烷化，并且是一种可能的特征，以及低粪便pH，右侧结直肠癌。

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