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首页> 外文期刊>International journal of colorectal disease. >Liver resection or cryotherapy for colorectal liver metastases A prospective case control study.
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Liver resection or cryotherapy for colorectal liver metastases A prospective case control study.

机译：结肠直肠肝脏转移的肝切除或冷冻疗法进行预期案例控制研究。

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BACKGROUND AND AIMS: While there is promising survival data for cryosurgery of colorectal liver metastases, local recurrence following cryoablation remains a problem. We aimed to compare morbidity and mortality, as well as the recurrence pattern and survival after liver resection and cryotherapy (alone or in combination with resection) for liver metastases. PATIENTS AND METHODS: Between 1996 and 2002, 168 patients underwent liver resection alone and 55 patients had cryotherapy (25 in combination with liver resection) for colorectal liver metastases. The patient, tumour and operative details were recorded prospectively and the two patient groups were compared regarding morbidity, survival and recurrence. RESULTS: More patients had a prior liver resection, liver metastases were smaller and less frequently synchronous, morbidity was significantly lower and hepatic recurrence was significantly more frequent in the cryotherapy group. Five-year survival rates following resection and cryotherapy were comparable (23 and 26% respectively), while overall and hepatic recurrence-free survival was inferior following cryotherapy. CONCLUSION: Cryotherapy is a valuable treatment option for some patients with non-resectable colorectal liver metastases. While survival is comparable to that after resection, higher hepatic recurrence rates following cryotherapy should caution against the use of cryotherapy for resectable disease until the results of randomized controlled trials are available.
机译：背景和宗旨：虽然具有与结直肠肝转移的冷冻乳沟的生存数据，但低温源后的局部复发仍然存在问题。我们的旨在比较发病率和死亡率，以及肝切除和冷冻疗法（单独或与切除组合）进行肝脏转移后的复发模式和存活。患者和方法：1996年至2002年间，168名患者接受肝切除肝切除和55名患者的冷冻疗法（25例与肝切除组合）进行结直肠肝脏转移。预期记录患者，肿瘤和手术细节，并在发病率，存活和复发方面进行比较两种患者群。结果：更多患者有先前的肝切除，肝转移较小，同步较小，发病率明显降低，冷冻疗法组中的肝复发显着更频繁。切除和冷冻疗法后的五年存活率可比较（分别为23％和26％），而总体而肝复发的存活率较差。结论：冷冻疗法是某些非可转移结直肠肝转移患者的有价值的治疗选择。虽然存活与切除后相当，但冷冻疗法后的肝复发率较高，应谨慎使用冷冻疗法，直至随机对照试验的结果可用。

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