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首页> 外文期刊>International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience >Changes in vascular density in resected tissue of 97 patients with mild malformation of cortical development, focal cortical dysplasia or TSC‐related cortical tubers
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Changes in vascular density in resected tissue of 97 patients with mild malformation of cortical development, focal cortical dysplasia or TSC‐related cortical tubers

机译：97例皮质发育轻微畸形的97例患者切除组织中血管密度的变化，局灶性皮质发育不良或TSC相关皮质块茎

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摘要

Recent studies suggested a possible association between malformations of cortical development and microvascular density. In this study we aimed to further elucidate the relation between microvascular density and cortical developmental abnormalities in a cohort of 97 patients with epilepsy and histologically proven mild malformation of cortical development (mMCD), focal cortical dysplasia (FCD) or tuberous sclerosis complex (TSC). Surgical tissue samples were analyzed with quantitative measures of vessel density, T‐cell response, microglial activation and myelin content. Subsequently, the results were compared to an age‐ and localization matched control group. We observed an increase in microvasculature in white matter of TSC cortical tubers, which is linked to inflammatory response. No increase was seen in mMCD or FCD subtypes compared to controls. In mMCD/FCD and tubers, lesional cortex and white matter showed increased vascular density compared to perilesional tissues. Moreover, cortical vessel density increased with longer epilepsy duration and older age at surgery while in controls it decreased with age. Our findings suggest for that the increase in white matter vascular density might be pathology‐specific rather than a consequence of ongoing epileptic activity. Increased cortical vessel density with age and with longer epilepsy duration in mMCD/FCD's and tubers, however, could be a consequence of seizures.
机译：最近的研究表明皮质发育和微血管密度畸形之间的可能关联。在这项研究中，我们旨在进一步阐明97例癫痫患者队列的微血管密度和皮质发育异常之间的关系，并组织学证明皮质发育（MMCD），局灶性皮层发育不良（FCD）或肺结乳复合体（TSC） 。通过血管密度，T细胞反应，小胶质激活和髓鞘含量的定量测量分析外科手术组织样品。随后，将结果与年龄和定位匹配对照组进行比较。我们观察到TSC皮质块茎白质中的微血管结构增加，与炎症反应有关。与控制相比，MMCD或FCD亚型中没有增加。在MMCD / FCD和块茎中，与血管组织相比，损伤皮质和白质显示出血管密度增加。此外，皮质血管密度随着较长的癫痫持续时间和旧时期在手术中增加而增加，同时随着年龄的增长而降低。我们的研究结果表明，白质血管密度的增加可能是有病理学的，而不是持续癫痫活动的结果。然而，增加皮质血管密度随着年龄的增长，并且在MMCD / FCD和块茎中具有更长的癫痫持续时间，但是，可能是癫痫发作的结果。

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