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首页> 外文期刊>International journal of gynecological pathology: Official journal of the International Society of Gynecological Pathologists >Synchronous Well-differentiated Endometrioid Adenocarcinoma and Leiomyosarcoma of the Uterus With Pulmonary Metastasis in a 50-Yr-Old Woman: A Case Report and Review of Literature
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Synchronous Well-differentiated Endometrioid Adenocarcinoma and Leiomyosarcoma of the Uterus With Pulmonary Metastasis in a 50-Yr-Old Woman: A Case Report and Review of Literature

机译：一个50年代女性肺转移的子宫同步良好分化的子宫内膜腺癌和平滑肌瘤：一个案例报告和文学审查

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摘要

The most common synchronous gynecologic malignancies are endometrial and ovarian cancers. However, synchronous endometrial adenocarcinoma and uterine leiomyosarcoma are extremely rare. We report the case of a 50-yr-old woman who was diagnosed with concomitant endometrial adenocarcinoma and uterine leiomyosarcoma. The sarcomatous neoplasm was positive for anti-smooth muscle actin and CD10, and focally positive for Cytokeratin AE1/AE3 and Cytokeratin Cam 5.2. She underwent total abdominal hysterectomy with bilateral salpingoopherectomy followed by radiation, brachytherapy, and chemotherapy. Three years later, she presented with cough and dyspnea and was found to have pulmonary metastasis. These tumor cells were positive for anti-smooth muscle actin, Cytokeratin AE1/AE3, Cytokeratin Cam 5.2, and epithelial membrane antigen, and therefore a diagnosis of lung metastasis from myometrial leiomyosarcoma was made. She received chemotherapy postoperatively. Currently, the patient has multiple lung metastases, is on Megestrol Acetate and is clinically well. This is the first reported case of concomitant uterine malignancies with pulmonary metastases and a long follow-up of 9 yr. It is important to rule out carcinosarcoma as a differential diagnosis in such patients.
机译：最常见的同步妇科恶性肿瘤是子宫内膜和卵巢癌。然而，同步子宫内膜腺癌和子宫平滑肌肉瘤非常罕见。我们举报了一个50年代女性的案例被诊断为伴随的子宫内膜腺癌和子宫平滑肌肉瘤。 Sarcomatous肿瘤对于抗光滑肌肌动蛋白和CD10是阳性的，并且致常见的细胞角蛋白AE1 / AE3和细胞角蛋白凸轮5.2。她接受了双侧肠外孢子切除术的总腹腔切除术，然后进行辐射，近距离放射治疗和化疗。三年后，她患有咳嗽和呼吸困难，发现具有肺转移。这些肿瘤细胞是抗光滑肌肌动蛋白，细胞角蛋白AE1 / AE3，细胞角蛋白凸轮5.2和上皮膜抗原的阳性，因此制备了肺部转移的肺转移。她术后接受了化疗。目前，患者有多种肺转移，是蜂醋酸盐，临床上。这是第一个报告的伴随肺转移的子宫恶性肿瘤的案例，并长期随访9年。排除癌症作为此类患者的差异诊断非常重要。

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