• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >Identification of most damaging nsSNPs in human CCR6 CCR6 gene: In silico analyses
【24h】

Identification of most damaging nsSNPs in human CCR6 CCR6 gene: In silico analyses

机译：鉴定人类CCR6 CCR6基因中大多数损伤NSSNPS：在硅分析中

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Single nucleotide polymorphisms in CCR6 (C–C chemokine receptor type 6) gene have been found to be the possible cause of many diseases like rheumatoid arthritis, psoriasis, lupus nephritis and systemic sclerosis and other autoimmune diseases. Therefore, identification of structurally and functionally important polymorphisms in CCR6 is important in order to study its potential malfunctioning and discovering therapeutic targets. Several bioinformatics tools were used to identify most damaging nsSNPs that might be vital for CCR6 structure and function. The in silico tools included PROVEAN, SIFT, SNP&GO and PolyPhen2 followed by I‐Mutant MutPred and ConSurf. Phyre2 and I‐TASSER were used for protein 3‐D Modelling while gene–gene interaction was predicted by STRING and GeneMANIA. Our study suggested that three nsSNPs rs1376162684 , rs751102128 and rs1185426631 are the most damaging in CCR6 gene while 7 missense SNPs rs1438637216 , rs139697820 , rs768420505 , rs1282264186 , rs1394647982 , rs769360638 and rs1263402382 are found to revert into stop codons. Prediction of post‐transcriptional modifications highlighted the significance of rs1376162684 because it effected potential phosphorylation site. Gene–gene interactions showed relation of CCR6 with other genes depicting its importance in several pathways and co‐expressions. In future, studying diseases related to CCR6 should include investigation of these 10 nsSNPs. Being the first of its type, this study also proposes future perspectives that will help in precision medicines. For such purposes, CCR6 proteins from patients of autoimmune diseases should be explored. Animal models can also be of significance find out the effects of CCR6 in diseases.
机译：摘要已发现CCR6（C-C趋化因子受体型6）基因中的单核苷酸多态性是类风湿性关节炎，牛皮癣，狼疮性肾炎和全身性硬化等自身免疫疾病等许多疾病的可能原因。因此，在CCR6中鉴定在结构上和功能重要的多态性是重要的，以研究其潜在的故障和发现治疗目标。几种生物信息学工具用于识别可能对CCR6结构和功能至关重要的大多数损坏的NSSNP。在Silico工具中包括普及，Sift，SNP＆amp; Go和Polyphen2，然后是I-Mutant Mutpry和Consurf。 PHYRE2和I-TASSER用于蛋白质3-D型造型，而串和Genemania预测基因-基因相互作用。我们的研究表明，三个NSSNPS RS1376162684，RS751102128和RS1185426631是CCR6基因中最损害的，而7号码SNPS RS1438637216，RS139697820，RS768420505，RS1394647986，RS769360638，RS769360638和RS1263402382恢复到停止密码子。转录后修改的预测突出了RS1376162684的意义，因为它效果潜在的磷酸化位点。基因基因相互作用显示CCR6与描绘其在几种途径和共同表达中重要性的其他基因的关系。将来，研究与CCR6相关的疾病应包括对这10个NSSNP的调查。作为其第一个类型，本研究还提出了将来有助于精密药物的未来观点。出于这种目的，应探索来自自身免疫疾病患者的CCR6蛋白。动物模型也具有重要性，从而了解CCR6在疾病中的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号