Characterization of a novel allelic variant in HLA‐B*46:01 HLA‐B*46:01 lineage, HLA‐B*46:01:25 HLA‐B*46:01:25 , by cloning, phasing and sequencing

Li LiXin; Tian Wei; Zhu FaMing; Wang WenYi; Wang Fan

首页> 外文期刊>International journal of immunogenetics >Characterization of a novel allelic variant in HLA‐B*46:01 HLA‐B*46:01 lineage, HLA‐B*46:01:25 HLA‐B*46:01:25 , by cloning, phasing and sequencing

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Characterization of a novel allelic variant in HLA‐B46:01 HLA‐B46:01 lineage, HLA‐B46:01:25 HLA‐B46:01:25 , by cloning, phasing and sequencing

机译：在HLA-B * 46中的新型等位基因变体的表征：01 HLA-B * 46：01谱系，HLA-B * 46：01：25，通过克隆，分阶段和测序

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Abstract A new allelic variant in HLA‐B*46:01 lineage, HLA‐B*46:01:25, has been identified in a male individual of Mongol ethnicity residing in northern China. Following polymerase chain reaction‐sequence‐based typing (PCR‐SBT), this novel variant was further confirmed by cloning, phasing and sequencing. HLA‐B*46:01:25 differs from HLA‐B*46:01:01 by a single synonymous T substitution at nucleotide position 137 (C ‐ T) in exon 4, corresponding to codon 228 (ACC‐ACT) of the mature HLA‐B mRNA molecule.

机译：摘要在HLA-B * 46中的一种新的等位基因变体：01血统，HLA-B * 46：01：25已被识别在中国北方蒙古族的雄性人物中。在基于聚合酶链反应序列的键入（PCR-SBT）之后，通过克隆，分阶测和测序进一步证实该新型变体。 HLA-B * 46：01：25通过在外显子4中的核苷酸位置137（C-T）处的单一同义T替换，对应于密码子228（ACC-ACT），不同于HLA-B * 46：01：01。成熟HLA-B mRNA分子。

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来源
《International journal of immunogenetics》 |2018年第6期|共4页
作者
Li LiXin; Tian Wei; Zhu FaMing; Wang WenYi; Wang Fan;
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作者单位

Immunogenetics Research Group Department of Immunology College of Basic Medical SciencesCentral;

Immunogenetics Research Group Department of Immunology College of Basic Medical SciencesCentral;

HLA Typing LaboratoryBlood Center of Zhejiang ProvinceHangzhou China;

Immunogenetics Research Group Department of Immunology College of Basic Medical SciencesCentral;

Immunogenetics Research Group Department of Immunology College of Basic Medical SciencesCentral;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
Chinese Mongolian population; cloning; HLA‐B*46:01:25; long‐range PCR; sequence‐based typing;

机译：中国蒙古人口;克隆;HLA-B * 46：01：25;远程PCR;基于序列的打字;

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1. Characterization of a novel allelic variant in HLA‐B*46:01 HLA‐B*46:01 lineage, HLA‐B*46:01:25 HLA‐B*46:01:25 , by cloning, phasing and sequencing [J] . Li LiXin, Tian Wei, Zhu FaMing, International journal of immunogenetics . 2018,第6期

机译：在HLA-B * 46中的新型等位基因变体的表征：01 HLA-B * 46：01谱系，HLA-B * 46：01：25，通过克隆，分阶段和测序
2. Detection of a novel HLA-B*46:01 variant, HLA-B*46:01:19, in a Taiwanese individual [J] . Lin Chun-Ying, Chang Chia-Ling HLA. . 2018,第6期

机译：检测新颖的HLA-B * 46：01变体，HLA-B * 46：01：19，在台湾个人中
3. Detection of a novel HLA-B*46:01 variant, HLA-B*46:01:22, in a Taiwanese individual [J] . Yang K. L., Chen S. -P., Lin P. Y. HLA. . 2016,第4期

机译：在台湾个体中检测到新型HLA-B * 46：01变体HLA-B * 46：01：22
4. Detection of HLA-B 13:01 gene among Dapsone hypersensitivity patients of leprosy in Papua Ethnics group using sequence based typing and qPCR rapid detection [C] . Hana Krismawati, Yustinus Maladan, Mohamad Fajri Rohman International Conference on Biological Science . 2020

机译：利用序列的键入和QPCR快速检测检测巴布亚尔族群落组白血管术中白酮超敏患者HLA-B 13:01基因
5. Mechanism of Outer Mitochondrial Membrane Associated Degradation Investigated by BioID of SLC25A46 [D] . Batty, Luke Daniel 2017

机译：SLC25A46 BioID研究线粒体外膜相关降解的机理
6. The intergenic recombinant HLA-B*46:01 has a distinctive peptidome which includes KIR2DL3 ligands [O] . Hugo G. Hilton, Curtis P. McMurtrey, Alex S. Han, -1

机译：基因间重组HLA-B * 46：01具有独特的肽组其中包括KIR2DL3配体
7. The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands [O] . Hugo G. Hilton, Curtis P. McMurtrey, Alex S. Han, 2017

机译：基因重组HLa-B * 46:01具有包含KIR2DL3配体的独特肽组

Characterization of a novel allelic variant in HLA‐B*46:01 HLA‐B*46:01 lineage, HLA‐B*46:01:25 HLA‐B*46:01:25 , by cloning, phasing and sequencing

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Characterization of a novel allelic variant in HLA‐B46:01 HLA‐B46:01 lineage, HLA‐B46:01:25 HLA‐B46:01:25 , by cloning, phasing and sequencing