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首页> 外文期刊>International journal of immunogenetics >Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population
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Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population

机译：白细胞介素10基因启动子多态性（RS1800896，RS1800871和RS1800872）和单倍型与伊朗人群中的系统性红斑狼疮和IL10水平的活性有关

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摘要

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown aetiology. According to the role of interleukin 10 (IL10) in SLE pathogenesis, the genetic alterations in its promoter region could be associated with elevated IL10 levels and exacerbated disease. Here, we investigated the association of genotype and haplotype frequencies of three IL10 gene promoter polymorphisms with susceptibility to SLE, IL10 plasma levels and disease activity of patients in an Iranian population. A total of 116 SLE patients and 131 healthy subjects were enrolled. The PCR-RFLP technique was used to detect IL10 promoter genotypes at the positions of -1082 (G/A), -819 (C/T) and -592 (C/A) in association with IL10 plasma levels and SLEDAI scores. The GG genotype of -1082 polymorphism was associated with the increased risk of SLE [OR = 2.65, 95% CI (1.21-5.82), p-value = 0.046]. The CC genotype in -819 region was associated with SLE susceptibility [OR = 3.38, 95% CI (1.26-9.07), p-value = 0.034] and C allele was introduced as risk allele [OR = 1.86, 95% CI (1.15-3.01), p-value = 0.009] in this region. IL10 plasma levels were overexpressed in CC genotype carriers of -592 SNP and decreased in AA genotype carriers of -1082. IL10 was also increased in SLE patients with CGT (-592/-1082/-819) haplotype. The SLEDAI score was higher among CC genotype carriers at the position of -592 and TT genotype carriers at the region of -819. SLEDAI was also elevated among patients with CGC (-592/-1082/-819) and CAC (p = 0.011) haplotypes. The present study suggests that the IL10 -819(C/T), -1082(G/A) and -592(C/A) polymorphisms and the haplotypes are associated with SLE susceptibility, increased disease activity and elevated IL10 levels. While this is the first time to report such an association in an Iranian population, further studies are needed to confirm these findings.
机译：Systemic Lupus红斑（SLE）是一种慢性自身免疫病，具有未知的病态。根据白细胞介素10（IL10）在SLE发病机制中的作用，其启动子区的遗传改变可能与IL10水平升高和加剧疾病相关。在这里，我们研究了三种IL10基因启动子多态性的基因型和单倍型频率与伊朗人群患者的SLE，IL10血浆水平和疾病活动的敏感性。共有116名SLE患者和131名健康受试者。 PCR-RFLP技术用于检测与IL10血浆水平和SLEDAI评分相关联的-1082（G / A），-819（C / T）和-592（C / A）的IL10启动子基因型。 -1082多态性的GG基因型与SLE [或= 2.65,95％CI（1.21-5.82），p值= 0.046]的风险增加有关。 -819区的CC基因型与SLE敏感性[或= 3.38,95％CI），P值= 0.034]和C等位基因作为风险等位基因[或= 1.86,95％CI（1.15 -3.01），P值= 0.009]在该地区。 IL10血浆水平在-592 snP的CC基因型载体中过表达，并且在-1082的AA基因型载体中降低。 IL10在SLE患者中也增加了CGT（-592 / -1082 / -819）单倍型。在-592和TT基因型载体的CC基因型载体中，SLEDAI得分高于-819的TT基因型载体。 CGC（-592 / -1082 / -819）和CAC（P = 0.011）单倍型，斯莱达也升高。本研究表明，IL10 -819（C / T），-1082（G / A）和-592（C / A）多态性和单倍型与SLE敏感性，增加的疾病活动和IL10水平升高有关。虽然这是在伊朗人群中举报这种协会第一次，但需要进一步研究来确认这些发现。

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