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首页> 外文期刊>International journal of immunogenetics >Phenotype frequencies of Rh (C, c, E, e), M, Mi(a) and Kidd blood group systems among ethnic Thai blood donors from the north-east of Thailand
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Phenotype frequencies of Rh (C, c, E, e), M, Mi(a) and Kidd blood group systems among ethnic Thai blood donors from the north-east of Thailand

机译：来自泰国东北部的族裔泰国献血者中RH（C，C，E，E），M，MI（A）和Kidd血液组系统的表型频率

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We here report the first study of antigen and phenotype frequencies of Rh (C, c, E, e), M, Mi(a) and Kidd antigens in north-east Thai blood donors. Blood transfusion services aim to ensure availability of adequate and safe blood to minimize the development of transfusion reactions. For pre-transfusion testing, the most important blood group systems are ABO and RhD. The transfusion of ABO-compatible otherwise unknown phenotype blood may result in alloimmunization, especially in multi-transfused patients. Extended red blood cell (RBC) phenotyping and selection of blood negative for specific antigens reduce post-transfusion complications and allow for effective blood transfusion regimens to be achieved. A total of 13,567 regular repeated, voluntary Thai blood donors were included for red-cell antigen typing of Rh (D, C, E, c, e). Samples from 12,768, 9,389 and 13,059 donors were typed for Kidd, M and Mi(a )antigens, respectively. Amongst Rh antigens, e was the most common (96.80%) followed by C (95.50%), c (34.40%) and E (32.20%) with CCDee (60.00%) being the most common phenotype. For Kidd phenotypes, Jk(a+b+) was the most common (46.73%) and Jk(a-b-) was rare (0.07%). For the M and Mi(a) antigen, M(+) was most frequently found (94.96%) and Mi(a)(+) was found in 17.97% of individuals. Knowledge of red-cell antigen phenotype frequencies in a population is helpful for creating a phenotype database of blood donors which can provide antigen-negative compatible blood to patients with multiple alloantibodies. Moreover, provision of antigen-matched blood can prevent alloimmunization in multi-transfused patients.
机译：我们在此报告了东北泰国献血者中RH（C，C，E，E），M，Mi（A）和基德抗原的抗原和表型频率的第一次研究。输血服务旨在确保充足和安全的血液的可用性，以尽量减少输血反应的发展。对于预输送测试，最重要的血液组系统是ABO和RHD。 ABO相容的输血否则未知的表型血液可能导致同种免疫，尤其是在多转灌注患者中。延长的红细胞（RBC）表型和对特异性抗原的血液阴性的选择减少输卵后并发症，并允许实现有效的血液输血方案。共有13,567次重复，志愿泰国献血者被包括RH（D，C，E，C，E）的红细胞抗原键入。分别为12,768,9,389和13,059种供体的样品分别用于KIDD，M和MI（A）抗原。在Rh抗原中，E是最常见的（96.80％），然后是C（95.50％），C（34.40％）和E（32.20％）（32.20％），CCDEE（60.00％）是最常见的表型。对于孩子，JK（A + B +）是最常见的（46.73％），JK（A-B-）罕见（0.07％）。对于M和Mi（A）抗原，最常发现M（+）（94.96％），17.97％的个体中发现了Mi（a）（+）。知识群体中的红细胞抗原表型频率有助于创建献血者的表型数据库，该表型可以向患有多种AlloAlibodies的患者提供抗原阴性相容的血液。此外，提供抗原匹配的血液可以防止多转药患者的同种异体化。

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