...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of immunogenetics >TIMP3 TIMP3 gene polymorphisms and relation to Ankylosing spondylitis susceptibility in Chinese Han population
【24h】

TIMP3 TIMP3 gene polymorphisms and relation to Ankylosing spondylitis susceptibility in Chinese Han population

机译：TIMP3 TIMP3基因多态性与中国汉族人群中脊柱膜炎易感性的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background Ankylosing spondylitis (AS) is a type of chronic progressive inflammatory disease, which often causes significant damage to the patients on the physical function, labour ability and quality of life. The study found that the enzyme system tissue inhibitor of matrix metalloproteinases ( TIMPs ) was important for the development of AS. The aim of this study was to investigate the association of polymorphisms of TIMP3 gene with AS in Chinese Han population. Methods To evaluate the correlation of TIMP3 polymorphisms with AS risk, Agena MassARRAY was used to determine the genotypes of 268 AS patients and 654 controls. The correlation between TIMP3 variants and AS risk was examined by unconditional logistic regression analysis. Haplotype construction and analysis in TIMP3 were also applied to detect the potential association. Results We identified that rs11547635 in the TIMP3 gene (odds ratio[OR]?=?0.79, 95% confidence intervals [CI]: 0.63–0.98, p ?=?.029) was significantly associated with a decreased risk of AS in the alleles model.?Rs715572 AG genotype (OR?=?1.57, 95% CI: 1.05–2.34, p ?=?.041) was potentially associated with an increased risk of AS, and also rs715572 in the dominant model (OR?=?1.61, 95% CI: 1.10–2.36, p ?=?.013) and log‐additive model (OR?=?1.41, 95% CI: 1.07–1.86, p ?=?.016) adjusted by age and gender were significantly correlated with an increased AS risk. Conclusion These findings suggested that polymorphisms of the TIMP3 gene may be associated with susceptibility to AS.
机译：摘要背景强调脊柱炎（AS）是一种慢性渐进性炎症疾病，往往对患者造成重大损害，患者对物理功能，劳动能力和生活质量。该研究发现，基质金属蛋白酶（TIMPS）的酶系统组织抑制剂对于开发是重要的。本研究的目的是探讨TIMP3基因多态性与中国汉族人群的多态性。评估TIMP3多态性与风险相关的方法，Agena Massarray用于确定患者和654例的268种基因型。通过无条件逻辑回归分析检查TIMP3变体与风险之间的相关性。 STIMP3中的单倍型结构和分析也被应用于检测潜在的关联。结果我们识别TIMP3基因的RS11547635（赔率比[或] =？0.79,95％置信区间[CI]：0.63-0.98，P？=β.029）与如此下降的风险显着相关。等位基因模型.?RS715572 AG基因型（或？=？1.57,95％CI：1.05-2.34，P？=Δ.041）可能与主要模型中的风险增加，并且还具有rs715572（或？= ？1.61,95％CI：1.10-2.36，p？=α.013）和日志添加剂模型（或？=？1.41,95％CI：1.07-1.86，P？= ?. 016）调整为年龄和性别与风险增加显着相关。结论这些发现表明，TIMP3基因的多态性可能与易感性有关。

著录项

  • 来源
  • 作者

    Wu Jiamin; Xiong Zichao; Sun Yao; Song Jiangjiang; Niu Fanglin; Yan Mengdan; Jin Tianbo;

  • 作者单位

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University;

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University;

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University;

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University;

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University;

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University;

    Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 免疫性疾病;
  • 关键词

    ankylosing spondylitis; case–control study; TIMP3 gene;

    机译：强直性脊柱炎;病例对照研究;TIMP3基因;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号