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首页> 外文期刊>International journal of immunogenetics >HLA‐specific memory B‐cell detection in kidney transplantation: Insights and future challenges
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HLA‐specific memory B‐cell detection in kidney transplantation: Insights and future challenges

机译：肾移植的HLA特异性记忆B细胞检测：见解和未来挑战

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Abstract Humoral alloimmunity mediated by anti‐human leucocyte antigen (HLA) antibodies is a major challenge in kidney transplantation and impairs the longevity of the transplanted organ. The immunological risk of an individual patient is currently mainly assessed by detection of HLA antibodies in the serum, which are produced by long‐lived bone marrow‐residing plasma cells. However, humoral alloimmunity is complex, and alloreactive memory B cells constitute an additional factor in the interplay of immune cells. These recirculating “silent” cells are responsible for the immunological recall response by differentiating into antibody‐producing cells upon antigen re‐encounter. Historically, due to the lack of appropriate and routinely applicable assays to determine the presence and HLA specificity of alloreactive memory B cells, their contribution to the humoral alloimmune response has clinically often been suspected but could not be determined. In this review, we give an overview of recent advances in techniques to detect alloreactive memory B cells and discuss their strengths and limitations. Furthermore, we summarize experiences with these techniques in alloimmunized individuals and transplant recipients, thereby emphasizing unmet needs to be addressed in future studies.
机译：摘要抗人类白细胞抗原（HLA）抗体介导的疏忽偶联是肾移植的主要挑战，损害移植器官的寿命。目前主要通过检测血清中的HLA抗体的HLA抗体来评估个体患者的免疫风险，这些抗体由长叶骨骨髓静脉耐等离子体细胞产生。然而，体液血管性是复杂的，并且占状记忆B细胞构成免疫细胞相互作用的额外因素。这些再循环的“沉默”细胞通过在抗原再遇到时分化成抗体产生的细胞负责免疫召回响应。从历史上看，由于缺乏适当和常规适用的测定来确定都是反应记忆B细胞的存在和HLA特异性，它们对体液同种症反应的贡献在临床上经常被怀疑，但无法确定。在本次审查中，我们概述了近期用于检测到占状记忆B细胞的技术的进步，并讨论其优势和局限性。此外，我们总结了在同种免疫的个体和移植受体中的这些技术的经验，从而强调未来的未来研究。

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