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首页> 外文期刊>International journal of geriatric psychiatry >Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials
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Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials

机译：旨在监测临床试验中认知功能变化的在线测试系统的实用性，可靠性，灵敏度和有效性

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Objective The advent of long‐term remotely conducted clinical trials requires assessments which can be administered online. This paper considers the utility, reliability, sensitivity and validity of an internet‐based system for measuring changes in cognitive function which is being used in one such trial. Methods The Platform for Research Online to investigate Genetics and Cognition in Ageing is a 10‐year longitudinal and entirely remote study launched in November 2015. The CogTrack TM System is being used to monitor changes in important aspects of cognitive function using tests of attention, information processing and episodic memory. On study entry, the participants performed CogTrack TM up to three times over seven days, and these data are evaluated in this paper. Results During the first six months of the study, 14?531 individuals aged 50 to 94 years enrolled and performed the CogTrack TM System, 8627 of whom completed three test sessions. On the first administration, 99.4% of the study tasks were successfully completed. Repeated testing showed training/familiarisation effects on four of the ten measures which had largely stabilised by the third test session. The factor structure of the various measures was found to be robust. Evaluation of the influence of age identified clinically relevant declines over the age range of the population on one or more measures from all tasks. Conclusions The results of these analyses identify CogTrack TM to be a practical and valid method to reliably, sensitively, remotely and repeatedly collect cognitive data from large samples of individuals aged 50 and over. Copyright ? 2017 John Wiley & Sons, Ltd.
机译：目的长期进行临床试验的出现需要评估，可以在线管理。本文考虑了基于互联网的效用，可靠性，灵敏度和有效性，用于测量在一个这样的试验中使用的认知功能的变化。方法对研究遗传和认知的研究平台是2015年11月推出的10年纵向和完全遥远的研究。CogTrack TM系统用于监测认知功能的重要方面的变化，使用注意力，信息加工和情节记忆。在学习条目上，参与者在七天内完成了CogTrack TM，在本文中评估了这些数据。结果在研究的前六个月内，14岁以下的人数为50至94岁，并进行了Cogtrack TM系统，其中8627年完成了三次测试会议。在第一届政府中，99.4％的研究任务已成功完成。重复测试显示对第三次测试会议主要稳定的十种措施中的四种措施的培训/熟悉影响。发现各种措施的因子结构是强大的。对年龄的影响评估在所有任务中对人口的年龄范围内确定了临床相关的下降。结论这些分析的结果鉴定了CogTrack TM，是一种实用和有效的方法，可靠地，敏感地，远程，远程，从50岁及以上的大型样品中收集认知数据。版权？ 2017年John Wiley＆amp; SONS，LTD.

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