...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of geriatric psychiatry >Factors affecting withdrawal and donation attrition in the brains for dementia research cohort
【24h】

Factors affecting withdrawal and donation attrition in the brains for dementia research cohort

机译：影响痴呆症研究队列大脑中戒断和捐赠磨损的因素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives To measure two forms of attrition in a cohort of volunteer brain donors: Withdrawal during life and non‐donation at death. To test whether cognitive impairment independently predicts attrition. Method Attrition rates were calculated for all registered participants and for all brain donors who had completed a baseline and follow‐up assessment of cognition, health, and lifestyle. Attrition reasons were described, and attrition rates were compared by gender, age group, and cognitive status. Multivariate logistic regression was used to identify the factors which independently predicted during life and at death. Results A total of 3276 brain donors registered and 2307 (70.4%) remained in the cohort. Attrition rate overall was 5.9% for withdrawal and 13.8% for donation. Family disagreement and the brain bank not being informed of participant death were the most common reasons for withdrawal and donation attrition. Withdrawal was associated with having cognitive impairment (OR 2.0 95% CI 1.1‐3.5), increased age (OR 3.1 95% CI 1.4‐6.9), and lower education (OR 1.8 95% CI 1.2‐2.8). Participants exhibiting cognitive decline between assessments were more likely to withdraw (OR 4.9 95% CI 1.7‐13.6). Participants living alone were almost twice as likely to die without donating (OR 1.9 95% CI 1.1‐3.3). Conclusions Attrition rates were relatively low, and consistent with other studies cognitive impairment, increased age, and less education predicted study withdrawal. Deaths of participants living alone were less likely to result in donation. Tailored, regular retention practices aimed at resolving family disagreement regarding donation decisions are required.
机译：目标是在志愿者脑捐赠者的队列中衡量两种形式的磨损：在生命期间撤回和捐赠死亡。测试认知障碍是否独立预测磨损。对于所有注册的参与者来说，对所有注册的参与者和所有脑捐助者进行了计算的方法磨损率和完成了对认知，健康和生活方式的后续评估。描述了磨损原因，并通过性别，年龄组和认知状态进行了磨损率。多变量逻辑回归用于识别在生命期间独立预测的因素和死亡。结果共计3276名脑捐助者，仍持有2307名（70.4％）。退出率的消耗率为5.9％，捐赠13.8％。家庭分歧和未经通知参与者死亡的大脑银行是退出和捐赠消耗的最常见原因。提取与具有认知障碍（或2.0 95％CI 1.1-3.5），年龄增加（或3.1 95％CI 1.4-6.9），以及降低教育（或1.8 95％CI 1.2-2.8）。参与者在评估之间表现出认知下降更可能撤回（或4.9 95％CI 1.7-13.6）。仅在不捐出的情况下，独自生活的参与者几乎是死亡的两倍（或1.9 95％CI 1.1-3.3）。结论磨损率相对较低，与其他研究认知障碍，年龄增加，较少教育预测研究撤离的差价率相对较低。独自生活的参与者的死亡人数不太可能导致捐赠。需要定制旨在解决关于捐赠决定的家庭分歧的定期保留实践。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号