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首页> 外文期刊>International journal of legal medicine >Automated determination of bone age from hand X-rays at the end of puberty and its applicability for age estimation
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Automated determination of bone age from hand X-rays at the end of puberty and its applicability for age estimation

机译：自动测定青春期结束时手X射线的骨龄的测定及其年龄估计的适用性

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The BoneXpert method for automated determination of bone age from hand X-rays was introduced in 2009, covering the Greulich-Pyle bone age ranges up to 17 years for boys and 15 years for girls. This paper presents an extension of the method up to bone age 19 years for boys and 18 years for girls. The extension was developed based on images from the First Zurich Longitudinal Study of 231 healthy children born in 1954-1956 and followed with annual X-rays of both hands until adulthood. The method was validated on two cross-sectional studies of healthy children from Rotterdam and Los Angeles. We found root mean square deviations from manual rating of 0.69 and 0.45 years in these two studies for boys in the bone age range 17-19 years. For girls, the deviations were 0.75 and 0.59 years, respectively, in the bone age range 15-18 years. It is shown how the automated bone age method can be applied to infer the age probability distribution for healthy Caucasian European males. Considering a population with age 15.0-21.0 years, the method can be used to decide whether the subject is above 18 years with a false positive rate (children classified as adults) of 10 % (95% confidence interval = 7-13%) and a false negative rate of 30 % (adults classified as children). To apply this method in other ethnicities will require a study of the average of "bone age - age" at the end of puberty, i.e. how much this population is shifted relative to the Greulich-Pyle standard.
机译：2009年引入了从手X射线自动测定骨骼年龄的骨蛋白蛋白蛋白蛋白伴骨龄的方法，覆盖了Greulich-Pyle骨骼年龄，男孩和15年的女孩为15年。本文介绍了男孩和18年的骨龄19年的方法的延伸。该延伸是基于来自1954年至1956年的第一个苏黎世纵向研究的图像开发的图像，并随后两只手的年X射线直到成年。该方法验证了来自鹿特丹和洛杉矶的健康儿童的两个横截面研究。我们发现从手工评级为0.69和0.45岁的手工等级，在这两项研究中为17-19岁的男孩。对于女孩来说，偏差分别为0.75％和0.59岁，骨骼年龄为15-18岁。显示如何应用自动骨骼年龄方法以推断出健康高加索欧洲男性的年龄概率分布。考虑到15.0-21.0岁的人口，该方法可用于决定该主题是否高于18年以上的假阳性率（归类为成年人）10％（95％置信区间= 7-13％）和假负率为30％（成年人被归类为儿童）。在其他种族中应用这种方法将需要研究青春期末的“骨龄龄”的平均值，即，这种人口相对于Greulich-Pyle标准的转变。

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