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首页> 外文期刊>International journal of molecular imaging >Visualization of Inflammation at Early Stage of Lung Cancer in Xenografted Temporally Immunosuppression Rats by Ferrioxamine Magnetic Resonance Imaging
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Visualization of Inflammation at Early Stage of Lung Cancer in Xenografted Temporally Immunosuppression Rats by Ferrioxamine Magnetic Resonance Imaging

机译：通过铁氧胺磁共振成像在异种移植颞下抑制大鼠肺癌早期炎症的可视化

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Physiological responses such as chronic inflammation and angiogenesis could be used as biomarkers for early detection of cancer with noninvasive imaging modalities. The present study reports the application of magnetic resonance imaging instrument to image the binding of ferrioxamine with hemin that allows visualizing the chronic inflammation foci of lung tissue of immunocompromised rats xenografted using small cell lung carcinoma. A low concentration of ferrioxamine (0.05 ± 0.02 muM·kg~(-1) of rat weight) deposited on tissue outside the vasculature was found to diffuse across the capillary walls to the interstitial space and inflammation foci, which provided a clear enhancement of T1-weighted gradient-echo sequence images. Ferrioxamine imaging allowed the determination of inflammatory sites and their localization in 3D fat-suppressed maximum intensity projections. The smallest dimension of foci that can be clearly determined is about 0.1 mm3. In concomitant to the in vivo imaging, analysis of histological tissue section showed the development of inflammatory sites. This study provides evidence that medical imaging instrument such as MRI scanner allows researchers to correlate images taken with MRI with those using high-resolution microscopy. Moreover, ferrioxamine is a useful molecular probe for determining chronic inflammation particularly at the very early stages of cancer.
机译：诸如慢性炎症和血管生成的生理反应可以用作生物标志物，用于早期检测与非侵入性成像方式的癌症。本研究报告磁共振成像仪施加磁共振成像仪与血红素的结合，允许使用小型细胞肺癌对免疫引起的免疫引发大鼠肺组织的肺组织慢性炎症灶。发现沉积在脉管系统外部的组织上的低浓度的甲氧化胺（0.05±0.02毫米·kg〜（-1）大鼠重量的大鼠重量，以扩散到间质空间和炎症灶上，这提供了T1的清晰增强 - 重量梯度回声序列图像。芳香胺成像允许测定炎症部位及其在3D脂肪抑制最大强度投影中的定位。可以清楚地确定的焦点的最小尺寸约为0.1mm3。在伴随体内成像时，组织学组织部分的分析表明炎症部位的发展。本研究提供了证据，即MRI扫描仪等医学成像仪器允许研究人员将使用高分辨率显微镜的MRI与MRI拍摄的图像相关联。此外，铁氧胺是一种有用的分子探针，用于确定慢性炎症，特别是在癌症的早期阶段。

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