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首页> 外文期刊>International journal of molecular medicine >Grape seed proanthocyanidins inhibit the proliferation, migration and invasion of tongue squamous cell carcinoma cells through suppressing the protein kinase B/nuclear factor-kappa B signaling pathway
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Grape seed proanthocyanidins inhibit the proliferation, migration and invasion of tongue squamous cell carcinoma cells through suppressing the protein kinase B/nuclear factor-kappa B signaling pathway

机译：葡萄籽花青素通过抑制蛋白激酶B /核因子-Kappa B信号通路来抑制舌鳞状细胞癌细胞的增殖，迁移和侵袭抑制舌鳞状细胞癌细胞的增殖，迁移和侵袭

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Tongue squamous cell carcinoma (TSCC) is the most common oral squamous cell carcinoma. Despite significant advances in combined therapies, the 5-year survival rate of patients with TSCC has not notably improved; this is due to regional recurrences and lymph node metastasis. Grape seed proanthocyanidins (GSPs) are consumed as dietary supplements worldwide and possess anticancer activity against several different types of cancer. However, their effect on TSCC and the underlying mechanisms by which they function remain unclear. In the present study, it was identified that GSPs significantly inhibited the viability and induced the apoptosis of Tca8113 cells in a dose-dependent manner. This was associated with a significantly increased expression of the pro-apoptosis regulator BAX protein and a significantly decreased expression of the anti-apoptosis regulator Bcl-2 protein at 100 mu g/ml GSPs. In addition, at non-toxic concentrations GSPs significantly inhibited the secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9 from Tca8113 cells, as well as their migration and invasion. Furthermore, it was demonstrated that GSPs significantly inhibited the phosphorylation of protein kinase B (Akt) and I kappa B kinase, as well as the translocation of nuclear factor-kappa B (NF-kappa B) into the nucleus of Tca8113 cells. Taken together, these results suggest that GSPs inhibit the proliferation, migration and invasion of Tca8113 cells through suppression of the Akt/NF-kappa B signaling pathway. This indicates that GSPs may be developed as a novel potential chemopreventive agent against TSCC.
机译：舌鳞状细胞癌（TSCC）是最常见的口腔鳞状细胞癌。尽管联合疗法有重大进展，但TSCC患者的5年生存率并不明显改善;这是由于区域复发和淋巴结转移。葡萄籽花香素蛋白（GSP）作为全球膳食补充剂消耗，并具有针对几种不同类型的癌症的抗癌活动。然而，它们对TSCC的影响和其功能的潜在机制仍然不清楚。在本研究中，鉴定了GSP显着抑制了活力并以剂量依赖性方式诱导TCA8113细胞的凋亡。这与促凋亡调节剂Bax蛋白的显着增加的表达有关，并且在100μg/ ml GSP时显着降低了抗凋亡调节剂Bcl-2蛋白的表达。此外，在无毒浓度下，GSP显着抑制来自TCA8113细胞的基质金属蛋白酶-2（MMP-2）和MMP-9的分泌，以及它们的迁移和侵袭。此外，证明GSP显着抑制蛋白激酶B（AKT）和IκB激酶的磷酸化，以及核因子-Kappab（NF-Kappa B）转移到TCA8113细胞核中的易位。总之，这些结果表明，GSP通过抑制AKT / NF-Kappa B信号通路来抑制TCA8113细胞的增殖，迁移和侵袭。这表明GSP可以被开发为针对TSCC的新型潜在化学预防剂。

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