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首页> 外文期刊>International journal of oral and maxillofacial surgery >Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial
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Evaluation of the efficacy of celecoxib and ibuprofen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: a randomized, controlled clinical trial

机译：对术后疼痛，肿胀和口腔开口的塞克昔布和布洛芬的疗效评价在手术中去除后的第三磨牙：随机，受控临床试验

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The objective of this study was to compare the efficacy of celecoxib and ibuprofen in reducing postoperative sequelae following the surgical removal of impacted mandibular third molars. Ninety-eight subjects who needed surgical extraction of an impacted mandibular third molar were selected for the study. All subjects were randomly allocated to receive one of the following treatments twice a day for 5 days after surgery: placebo (n = 32), ibuprofen (n = 33), or celecoxib (n = 33). The primary outcome chosen was postoperative pain, which was evaluated using the visual analogue scale (VAS) score recorded by each patient. The secondary outcomes chosen were changes in postoperative swelling and maximum mouth opening values compared to preoperative ones. Compared to placebo, treatment with celecoxib and ibuprofen resulted in improvements in the primary outcome. Furthermore, when compared to the other groups, patients in the celecoxib group showed a significant reduction in postoperative pain scores at 6 h (P < 0.001), 12 h (P = 0.011), and 24 h (P = 0.041) after surgery. Regarding swelling and maximum mouth opening values, there were no significant differences between the groups at each follow-up session. This study demonstrated that treatment with celecoxib decreased the incidence and severity of postoperative pain following third molar surgery compared to ibuprofen and placebo.
机译：本研究的目的是将Celecoxib和布洛芬的疗效进行比较在手术去除颌下下颌三臼齿后减少术后后遗症。选择九十八次需要受冲击下颌三摩尔的手术提取的受试者进行研究。随机分配所有受试者，在手术后每天每天两次接受以下治疗方法，使得安慰剂（n = 32），布洛芬（n = 33），或塞枯oxib（n = 33）。选择的主要结果是术后疼痛，使用每个患者记录的视觉模拟量表（VAS）评分评估。选择的二次结果是与术前肿胀和最大口开口值的变化。与安慰剂相比，用Celecoxib和布洛芬治疗导致主要结果的改善。此外，与其他组相比，Celecoxib组的患者在手术后6小时（P <0.001），12小时（P = 0.011）和24小时（P = 0.041），术后疼痛评分显着降低。关于肿胀和最大嘴开口值，每个后续会话的组之间没有显着差异。本研究表明，与布洛芬和安慰剂相比，在第三磨牙手术后，塞克罗克布治疗降低了术后疼痛的发病率和严重程度。

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