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首页> 外文期刊>International journal of oral and maxillofacial surgery >Hypoxic volume evaluated by F-18-fluoromisonidazole positron emission tomography (FMISO-PET) may be a prognostic factor in patients with oral squamous cell carcinoma: preliminary analyses
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Hypoxic volume evaluated by F-18-fluoromisonidazole positron emission tomography (FMISO-PET) may be a prognostic factor in patients with oral squamous cell carcinoma: preliminary analyses

机译：由F-18-氟代咪唑正电子发射断层扫描（FMISO-PET）评估的缺氧体积可以是口腔鳞状细胞癌患者的预后因素：初步分析

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Tumour hypoxia can be detected by F-18-fluoromisonidazole positron emission tomography (FMISO-PET). Few studies have assessed the relationships of new PET parameters, including hypoxic volume (HV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG), with 5-year survival of patients treated surgically for oral squamous cell carcinoma (OSCC). This study evaluated the relationships between these PET parameters and 5-year survival in OSCC patients. Twenty-three patients (age 42-84 years; 15 male, eight female) with OSCC underwent FMISO- and F-18-fluoro-2-deoxyglucose (FDG)-PET computed tomography before surgery. All of them underwent radical surgery and were followed up for more than 5 years. The FDG-PET maximum standardized uptake value (SUVmax), HV, MTV, and TLG were measured. The ability of PET parameters to predict disease-free survival (DFS) and loco-regional recurrence (LR) was evaluated using receiver operating characteristic curve analysis. During the follow-up period, five of the 23 patients (22%) died and six (26%) experienced LR. Although FDG-PET SUVmax was not significantly associated with DFS or LR, HV correlated significantly with both DFS and LR. TLG, but not MTV, was significantly associated with DFS; however neither MTV nor TLG was related significantly to LR. In conclusion, tumour HV may predict outcomes in patients with OSCC.
机译：肿瘤缺氧可以通过F-18-氟代咪唑正电子发射断层扫描（FMISO-PET）来检测。少数研究评估了新的宠物参数的关系，包括缺氧体积（HV），代谢肿瘤体积（MTV）和总损伤糖酵解（TLG），用于口腔鳞状细胞癌（OSCC）手术治疗的患者的5年生存期。该研究评估了OSCC患者这些宠物参数与5年生存之间的关系。二十三名患者（年龄42-84岁; 15名男性，八个女性）随着OSCC接受FMISO和F-18-氟-2-脱氧葡萄糖（FDG） - 在手术前进行了计算机断层扫描。所有这些都接受了激进的手术，并随访了超过5年。测量FDG-PET最大标准化摄取值（SUVMAX），HV，MTV和TLG。使用接收器操作特性曲线分析评估PET参数预测无病存活（DFS）和LOCO-区域复发（LR）的能力。在随访期间，23例患者中的五个（22％）死亡，六（26％）经验丰富的LR。虽然FDG-PET SUVMAX与DFS或LR没有显着相关，但HV与DFS和LR显着相关。 TLG，但不是MTV，与DFS显着相关;然而，MTV和TLG都没有显着相关到LR。总之，肿瘤HV可以预测OSCC患者的结果。

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