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首页> 外文期刊>BJU international >Genetic changes in stage pT2N0 prostate cancer studied by comparative genomic hybridization.
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Genetic changes in stage pT2N0 prostate cancer studied by comparative genomic hybridization.

机译：通过比较基因组杂交研究了pT2N0期前列腺癌的遗传变化。

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OBJECTIVE: To identify chromosomal regions important for progression in clinically organ-confined prostate cancer, as the genetic changes underlying the development and progression of prostate cancer are poorly understood. MATERIALS AND METHODS: Comparative genomic hybridization (CGH) was used to search for DNA sequence copy-number changes in a series of 50 primary organ-confined prostate adenocarcinomas (pT2N0) removed by radical prostatectomy. RESULTS: CGH analysis indicated that 23 (46%) of the primary prostate adenocarcinomas showed chromosome alterations. The percentage of tumours with losses (38%) was higher than with gains (28%). Losses of 13q (24%), 8p (18%), 6q (10%), 16q (8%), 18q (6%) and 5q (6%) and gains of 17q (12%), 20q (12%), 9q (10%), 17p (8%) and 8q (6%) were the most frequent alterations. Amplifications were found at 8q24-qter. Minimal overlapping regions of loss, indicative of the presence of tumour-suppressor genes, were mapped to 13q21.1-q21.3 and 8p21.2, and minimal overlapping regions of gain, indicative of the presence of oncogenes, were found at 9q34.4-qter, 17q25-qter and 20q13.3-qter. There was a significant association between Gleason score and losses and gains (P = 0.003), and an association between chromosomal imbalance and high histological grade (P = 0.008). CONCLUSION: These results suggest that losses or gains of DNA in these regions are important for prostate cancer progression, and document the spectrum of chromosomal alterations in stage pT2N0 of clinically organ-confined prostate cancer.
机译：目的：鉴定对临床上局限性前列腺癌的进展至关重要的染色体区域，因为对前列腺癌的发生和发展的遗传改变知之甚少。材料与方法：比较基因组杂交（CGH）用于搜索经根治性前列腺切除术切除的一系列50例原发性局限性前列腺腺癌（pT2N0）中的DNA序列拷贝数变化。结果：CGH分析表明，原发性前列腺腺癌中有23例（46％）显示染色体改变。肿瘤丢失的比例（38％）高于肿瘤增加的比例（28％）。亏损13q（24％），8p（18％），6q（10％），16q（8％），18q（6％）和5q（6％）以及17q（12％），20q（12％）的收益），9q（10％），17p（8％）和8q（6％）是最常见的变化。在8q24-qter发现扩增。指示肿瘤抑制基因存在的最小丢失重叠区域被定位到13q21.1-q21.3和8p21.2，而发现最小重叠的表达区域表示癌基因存在于9q34。 4-qter，17q25-qter和20q13.3-qter。格里森评分与损益之间存在显着相关性（P = 0.003），染色体失衡与组织学分级高之间存在相关性（P = 0.008）。结论：这些结果表明在这些区域中DNA的丢失或增加对于前列腺癌的进展很重要，并记录了临床上受器官限制的前列腺癌的pT2N0期的染色体改变谱。

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