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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplantation
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Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplantation

机译：移植后第一年雌性肾移植受者在雌性肾移植受者中的重要性

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Objectives. Most of human papillomavirus (HPV) infections are “cleared” by the immune system; however, in cases of immune system suppression, infections could lead to development of malignancies. The aim of this study was to find out the frequency of HR-HPV infection in early period after renal transplantation in recipients receiving immunosuppressive therapy and to follow the progression of the infection up to one year. Methods. 43 female renal transplant recipients and 79 healthy female individuals as a control group were enrolled in this investigation. For the detection of HPV infection, patients’ samples (blood and vaginal swabs) were collected two weeks after transplantation with following collection of six months and one year. Different polymerase chain reactions for HR-HPV genomic sequences detection and ELISA kit for detection of anti-HPV IgG antibodies were used. Results. In this study, we show that frequency rate of HR-HPV infection has increased in the first year after transplantation from early stage of immunosuppressive therapy (from 24% to 36%). Also an increase of HR-HPV load was detected over time, showing the highest median viral load at sixth month after transplantation. Conclusions. From the obtained data, it follows that it is very important to carefully monitor patients receiving immunosuppression therapy on progression of HR-HPV.
机译：目标。大多数人乳头瘤病毒（HPV）感染由免疫系统“清除”;然而，在免疫系统抑制的情况下，感染可能导致恶性肿瘤的发展。本研究的目的是在接受免疫抑制疗法接受受者肾移植后的早期发现HR-HPV感染的频率，并遵循一年的感染进程。方法。 43例雌性肾移植受者和79名健康女性个人作为对照组进行了纳入这一调查。对于检测HPV感染，患者的样品（血液和阴道拭子）在移植后两周收集，随后收集六个月和一年。使用用于检测抗HPV IgG抗体的HR-HPV基因组序列检测和ELISA试剂盒的不同聚合酶链反应。结果。在这项研究中，我们表明，从免疫抑制治疗早期移植后的第一年（从24％到36％），HR-HPV感染的频率率增加。随着时间的推移，检测到HR-HPV载荷的增加，显示移植后第六个月的最高中值病毒负载。结论。从获得的数据中，仔细监测接受免疫抑制治疗的患者对HR-HPV进行的患者非常重要。

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