• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American journal of medical genetics, Part B. Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics >Longitudinal interplays of estrogen receptor alpha gene rs9340799 with social-environmental factors on post-traumatic stress disorder in Chinese Han adolescents after Wenchuan earthquake
【24h】

Longitudinal interplays of estrogen receptor alpha gene rs9340799 with social-environmental factors on post-traumatic stress disorder in Chinese Han adolescents after Wenchuan earthquake

机译：雌激素受体α基因RS9340799与汶川地震后中国汉族青少年后创伤后应激障碍的社会环境因素的纵向相互作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Indirect evidences suggested associations of estrogen receptor alpha (ESR1) with post-traumatic stress disorder (PTSD). However, the relationship between rs9340799 on ESR1 gene and PTSD has not been reported yet. The present study was to explore the longitudinal changes of prevalence and severity of PTSD in adolescents with different genotypes of rs9340799 after the 2008 Wenchuan earthquake. Social-environmental factors were collected by questionnaires in 465 high school students. Variants of rs9340799 were determined by polymerase chain reaction-restriction fragment length polymorphism analyses and verified by DNA sequencing. PTSD symptoms were assessed by PTSD Checklist-Civilian Version (PCL-C) at 6, 12, and 18 months after the earthquake. The female AA homozygotes had a trend of higher prevalence of PTSD and significantly higher PCL-C scores than the female G allele carriers at 6 months after the earthquake. The female students had higher prevalence of PTSD and higher PCL-C scores than the male subjects at 6 months in the AA homozygotes, but not in the G allele carriers. Consecutive decreases in PCL-C scores were observed only in the female AA homozygotes. Only in the female, the AA genotype was the risk factor and predictor of PCL-C scores at 6 months. Potential factors of PTSD prevalence and predictors of PCL-C scores were different between the AA homozygotes and G allele carriers at different time during the follow-up. These results suggest gene-environment interactions may occur among rs9340799 and social-environmental factors, and influence the development and natural rehabilitation of PTSD in the course after stressed by the earthquake.
机译：间接证据表明雌激素受体α（ESR1）与创伤后应激障碍（PTSD）的关联。但是，尚未报告ESR1基因和PTSD上的RS9340799之间的关系。本研究是在2008年汶川地震后探讨青少年中PTSD患有PTSD的纵向和严重程度的纵向变化，不同的基因型。 465名高中生问卷收集了社会环境因素。 RS9340799的变体由聚合酶链反应限制片段长度多态性分析并通过DNA测序验证。 PTSD症状由PTSD清单 - 民用版（PCL-C）在地震后6,12和18个月内评估。雌性AA Homozygotes在地震发生后6个月内具有比雌性G等位基因载体更高的PTSD患病率和显着更高的PCL-C分数。女性学生的PTSD和更高的PCL-C分数比男性受试者在AA HOMOZYGOTES的6个月内患病，但不在G等位基因载体中。仅在雌性AA纯合子中仅观察到PCL-C分数的连续减少。仅在女性中，AA基因型是在6个月内的PCL-C分数的危险因素和预测因子。在随访期间不同时间的AA homozygotes和G等位基因载体之间的PTSD患病率和PCL-C分数预测因子的潜在因素不同。这些结果表明基因环境相互作用可能发生在RS9340799和社会环境因素之间，并影响受地震压力后应激障碍的发展和自然康复。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号