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首页> 外文期刊>American journal of medical genetics, Part B. Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics >Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders
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Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders

机译：儿童面部情感识别的基因组关联研究与心理健康障碍的多基因风险联合

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摘要

Emotion recognition is disrupted in many mental health disorders, which may reflect shared genetic aetiology between this trait and these disorders. We explored genetic influences on emotion recognition and the relationship between these influences and mental health phenotypes. Eight-year-old participants (n = 4,097) from the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Diagnostic Analysis of Non-Verbal Accuracy (DANVA) faces test. Genome-wide genotype data was available from the Illumina HumanHap550 Quad microarray. Genome-wide association studies were performed to assess associations with recognition of individual emotions and emotion in general. Exploratory polygenic risk scoring was performed using published genomic data for schizophrenia, bipolar disorder, depression, autism spectrum disorder, anorexia, and anxiety disorders. No individual genetic variants were identified at conventional levels of significance in any analysis although several loci were associated at a level suggestive of significance. SNP-chip heritability analyses did not identify a heritable component of variance for any phenotype. Polygenic scores were not associated with any phenotype. The effect sizes of variants influencing emotion recognition are likely to be small. Previous studies of emotion identification have yielded non-zero estimates of SNP-heritability. This discrepancy is likely due to differences in the measurement and analysis of the phenotype.
机译：情感识别在许多心理健康障碍中被扰乱，这可能反映了这种特质和这些障碍之间的共同遗传疾病。我们探讨了对情感认可的遗传影响和这些影响与心理健康表型之间的关系。八岁的参与者（N = 4,097）来自禽流徒纵向研究的父母和儿童（ALSPAC）完成了非言语精度（DANVA）面部测试的诊断分析。来自Illumina Humanhap550四分之一的微阵列获得的基因组基因型数据。进行基因组协会研究，以评估具有识别个人情绪和情感的协会。使用已公布的精神分裂症，双相障碍，抑郁，自闭症谱系，厌食症和焦虑症进行的探索性多基因风险评分进行。在任何分析中，在任何分析中没有在常规显着性中鉴定单个遗传变体，尽管在提示意义的暗示性的水平相关。 SNP芯片遗传性分析未识别任何表型的差异的遗传组分。多基因分数与任何表型无关。影响情绪识别的变体的效果大小可能很小。以前对情感鉴定的研究产生了不归零的SNP-REVITATIB。这种差异很可能是由于表型测量和分析的差异。

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