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首页> 外文期刊>International journal of toxicology >Interspecies Comparison of Control Data From Embryo–Fetal Development Studies in Sprague-Dawley Rats, New Zealand White Rabbits, and G?ttingen Minipigs
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Interspecies Comparison of Control Data From Embryo–Fetal Development Studies in Sprague-Dawley Rats, New Zealand White Rabbits, and G?ttingen Minipigs

机译：Sprague-Dawley大鼠胚胎胎儿开发研究中的控制数据的间歇性比较，新西兰白兔，G？Ttingen Minipigs

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Species-dependent differences in relative incidence of spontaneous variations and malformations should be considered in the assessment of the translational value of reproductive and developmental safety assessments. The objective of this evaluation was to compare litter parameters and the frequency of external, visceral, and skeletal malformations and variations across species in the Sprague-Dawley rat, New Zealand White rabbit, and G?ttingen minipig and to determine whether notable differences exist. Pregnant female rats (n = 824), rabbits (n = 540), and minipigs (n = 70) from vehicle control groups were included in the analysis, equating to 10,749 rat, 5,073 rabbit, and 378 pig fetuses collected at term by cesarean delivery. Preimplantation loss was more frequent than postimplantation loss in the rat and rabbit, whereas the opposite was observed in the minipig. Several external and visceral malformations and variations such as domed head, bent tail, abdominal edema, and anal atresia were observed in all 3 species. Visceral malformations of the heart and major blood vessels were remarkably more frequent in the minipig and rabbit, respectively; ventricular and atrium septum defects were observed in 1.9% and 2.1%, respectively, for the minipig fetuses, whereas they were observed in equal or less than 0.02% among the rat and rabbit fetuses evaluated in this study. Understanding species-dependent differences in spontaneous variations and malformations can be useful for the interpretation of embryo–fetal development study results. The current analysis identified relevant differences between commonly used species in reproductive toxicology with potential implications for data assessment.
机译：在评估生殖和发育安全评估的翻译价值时，应考虑自发变化和畸形的相对发生率的物种依赖性差异。该评估的目的是将垃圾参数和外部，内脏和骨骼畸形的频率进行比较，并在Sprague-Dawley Rat，新西兰白兔和G？Ttingen Minipig中的种类的变化，并确定是否存在显着差异。在分析中，包括载体对照组的兔子（n = 824），兔子（n = 540）和小磷脂（n = 70），等于10,749只大鼠，5,073只兔和378个猪胎儿通过剖腹产送货。在大鼠和兔子中，预致病损失比后免疫损失更频繁，而在MINIPIG中观察到相反。在所有3种中观察到几种外部和内脏畸形和诸如圆顶，弯曲的尾巴，腹部水肿和肛门闭锁的变化。在MINIPIG和兔子中，心脏和主要血管的内脏畸形显着更频繁;对于Minipig胎儿分别以1.9％和2.1％观察到心室和心室隔膜缺陷，而在该研究中评估的大​​鼠和兔胎儿中，它们在等于或小于0.02％的情况下观察到。了解自发变化和畸形的物种依赖性差异对于胚胎胎儿发育研究结果的解释是有用的。目前的分析确定了生殖毒理学常用物种之间的相关差异，具有数据评估的潜在影响。

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