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The SFC isolation and Purification of Cannabinoids using Application Specific Stationary Phases under optimised conditions

机译：在优化条件下使用施用特异性固定阶段的CFC分离和纯化大麻素

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摘要

Cannabis sativa is comprised of hundreds of individual compounds that can be classified in many chemical families, such as terpenes, amino acids, fatty acids, hydrocarbons, flavonoids, sugars and cannabinoids. Cannabinoids represents a class of chemicals that are classified as terpenophenolic compounds. There are about 70 terpenophenolic compounds in the cannabinoid class. These are only found in cannabis plants. Of the 70 cannabinoids found in Cannabis there are several cannabinoids that are of human physiological and medicinal interest. These include the psychoactive Δ-9-tetrahydrocannabinol (THC), non-psychoactive cannabidiol (CBD) and the non-psychoactive tetrahydrocannabivarin (THCV). THC, THCV and CBD are neutral forms of cannabinoids, obtained after a nonenzymatic decarboxylation of delta 9-tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarinic acid (THCVA) and cannabidiolic acid (CBDA). It is the focus of this manuscript to utilise SFC chromatographic stationary phases that have been specifically developed for the isolation and purification of THCA, CBDA, THC, CBD and THCV. These specific cannabinoids require the use of several different stationary phases for optimised separation and purification of them individually.
机译：大麻Sativa由数百种唯一的化合物组成，可在许多化学家族中分类，例如萜烯，氨基酸，脂肪酸，烃，黄酮类，糖和大麻素。大麻素代表一类被分类为三萜胶化合物的化学品。大麻素类中有大约70萜烯酚化合物。这些仅在大麻植物中找到。在大麻中发现的70种大麻素有几种是人类生理和药用利益的大麻素。这些包括精神活性δ-9-四氢甘露那尼罗酚（THC），非精神活性大麻（CBD）和非精神活性四氢萘糖蛋白（THCV）。 THC，THCV和CBD是大麻素的中性形式，在δ9-四氢甘油酸（THCA），四氢甘油酸（THCVA）和大麻酸（CBDA）的非酶脱羧后获得。该稿件的重点是利用SFC色谱静止相，专门用于分离和纯化ThCA，CBDA，THC，CBD和THCV的分离和纯化。这些特定的大麻素需要使用几种不同的固定阶段，以单独优化它们的优化分离和纯化。

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