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首页> 外文期刊>Acute pain: international journal of acute pain management >The perioperative infusion of low doses of magnesium sulfate reduces analgesic requirements in patients undergoing abdominal hernioplasty
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The perioperative infusion of low doses of magnesium sulfate reduces analgesic requirements in patients undergoing abdominal hernioplasty

机译：围手术期输注小剂量硫酸镁可降低接受腹部疝成形术的患者的镇痛需求

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摘要

Magnesium sulfate, which is an antagonist of the N-methyl-D-aspartate (NMDA) receptor and a physiological calcium channel blocker, has analgesic properties in a number of acute and chronic pain conditions. The aim of our study was to evaluate whether intravenous administration of low doses of magnesium during anaesthesia would reduce analgesic requirements intraoperatively and in the early postoperative period.In a prospective, randomized, double-blinded and placebo-controlled study, 42 patients undergoing abdominal hernioplasty in balanced general anaesthesia, with sevoflurane, N_2O, fentanyl and rocuronium, received intravenously, either magnesium sulfate 10%, a bolus of 30mgkg~(-1) before start of surgery and an infusion of 6 mg ( kg~(-1) h~(-1)) over the entire operation period, or isotonic sodium chloride (control group). Intra- and postoperative analgesia were achieved with fentanyl.Our results showed that fentanyl consumption intra-and postoperatively was significantly less in the magnesium group and with no adverse events. The requirements of muscle relaxants did not differ significantly between the groups. We conclude that magnesium sulfate in lower bolus and infusion doses than those used in previous studies is an effective adjuvant for perioperative analgesic management.
机译：硫酸镁是N-甲基-D-天冬氨酸（NMDA）受体的拮抗剂和生理性钙通道阻滞剂，在许多急性和慢性疼痛情况下均具有镇痛作用。本研究的目的是评估麻醉期间静脉内低剂量镁的注射是否会降低术中和术后早期的镇痛要求。在一项前瞻性，随机，双盲和安慰剂对照研究中，有42例患者接受了腹部疝气成形术在全身麻醉的平衡下，在手术开始前静脉注射七氟醚，N_2O，芬太尼和罗库溴铵，硫酸镁10％，推注30mgkg〜（-1），输注6mg（kg〜（-1）h在整个手术期间〜（-1））或等渗氯化钠（对照组）。芬太尼可实现术中和术后镇痛效果。我们的研究结果表明，镁组的芬太尼在术中和术后的消耗量明显减少，且无不良事件发生。两组之间肌肉松弛剂的需求无明显差异。我们得出的结论是，硫酸镁的推注和输注剂量比以前的研究中使用的剂量低，是围手术期镇痛管理的有效佐剂。

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