...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acute pain: international journal of acute pain management >A prospective randomized pragmatic double-blinded comparison of 0.125% and 0.0625% bupivacaine for the management of pain after operation in patients undergoing major abdominal surgery
【24h】

A prospective randomized pragmatic double-blinded comparison of 0.125% and 0.0625% bupivacaine for the management of pain after operation in patients undergoing major abdominal surgery

机译：大腹部手术患者布比卡因0.125％和0.0625％布比卡因的前瞻性随机语用双盲比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The aim of this prospective, pragmatic, double-blind, randomized controlled trial was to investigate the analgesic and adverse effects of two concentrations of thoracic epidural bupivacaine in patients undergoing major abdominal surgery. Our primary aim was to reduce the incidence of hypotension resulting from effective epidural analgesia.Methods: We studied 100 patients who were randomized to receive either 0.0625% bupivacaine or 0.125% bupivacaine, both with diamorphine, via a thoracic epidural. Dynamic pain was measured using a verbal ranking score and visual analogue scores. Results: No statistically significant difference was found between infusion rates or dynamic pain scores. A significantly greater number of patients receiving 0.125% bupivacaine, 63% versus 39%, were hypotensive on the day of surgery (p = 0.027). Thereafter, the trend continues but was not statistically significant.Conclusion: We were able to demonstrate that the incidence of hypotension was reduced with 0.0625% bupivacaine without affecting the quality of pain relief. However the overall incidence of hypotension remained high which restricted early mobilisation in some patients. Hypotension may be unavoidable when epidurals effectively control postoperative pain.
机译：背景：这项前瞻性，务实，双盲，随机对照试验的目的是研究两种浓度的胸膜硬膜外布比卡因对大腹部手术患者的镇痛作用和不良反应。我们的主要目的是减少有效硬膜外镇痛引起的低血压发生率。方法：我们研究了100名随机经胸膜硬膜外接受二甲吗啡的0.0625％布比卡因或0.125％布比卡因的患者。使用语言等级评分和视觉模拟评分来测量动态疼痛。结果：输注速率或动态疼痛评分之间无统计学差异。在手术当天，接受0.125％布比卡因治疗的患者血压明显降低（63％和39％）（p = 0.027）。此后，这种趋势仍在继续，但没有统计学意义。结论：我们能够证明使用0.0625％布比卡因降低了低血压的发生率，而没有影响止痛的质量。然而，低血压的总发生率仍然很高，这限制了某些患者的早期动员。当硬膜外药物有效控制术后疼痛时，低血压可能是不可避免的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号