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首页> 外文期刊>International journal of psychophysiology: official journal of the International Organization of Psychophysiology >Common and specific dimensions of internalizing disorders are characterized by unique patterns of brain activity on a task of emotional cognitive control
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Common and specific dimensions of internalizing disorders are characterized by unique patterns of brain activity on a task of emotional cognitive control

机译：内化疾病的常见和特异性尺寸的特征在于对情绪认知控制的任务的脑活动独特的脑活动模式

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Alterations in neural systems underlying cognitive control are well-documented across individuals with various internalizing disorders. The current study examined how individual differences in underlying traits related to internalizing disorders influence brain activation, as assessed by fMRI, when cognitive control must be exerted to make a decision about the emotional valence (positive, negative) of a task-relevant word displayed concurrently with a task-irrelevant emotional face. Taking a bi-factor model approach, fifty-five middle-aged female participants were characterized on symptom level on a common internalizing latent factor representing shared symptoms across anxiety and depression, as well as on specific factors remaining after taking the common internalizing factor into account: low positive affect, anxious arousal, and anxious apprehension. Contrasting activation on trials requiring higher vs. lower control revealed that higher levels of the Common Internalizing factor are associated with less deactivation of regions of the default mode network. Higher levels of the Low Positive Affect-specific factor are associated with less differentiation in engagement of portions of the frontoparietal control network, while higher levels of the Anxious Arousal-specific factor are associated with less of a differentiation in activation of the thalamus. No effects were observed for level of the Anxious Apprehension-specific factor. These results suggest that prior findings of alterations in default mode activity associated with depression may not be specific to depressive symptoms per se but may characterize internalizing symptoms more generally. In addition, they suggest that reduced engagement of cognitive control regions may be more associated with low positive affect than depressive symptoms more generally.
机译：神经系统的改变潜在的认知控制在具有各种内化疾病的个体上良好地记录。目前的研究检查了与内化疾病相关的潜在特征的个体差异如何影响脑激活，如FMRI评估，当必须施加认知控制，以决定与同时显示的任务相关词的情绪化价（正负）决定有一个任务无关的情感脸。采取双因素模型方法，五十五名中年女性参与者的特征在于症状水平，症状水平在焦虑和抑郁症的共同症状，以及在考虑公共内化因素后剩余的特定因素：阳性影响，焦虑令人焦虑和焦虑的忧虑。对较低对照的试验的对比激活较低的控制揭示了较高水平的公共内化因子与默认模式网络的区域的失活相关联。较高水平的低阳性影响特异性因子与前期控制网络的部分接合的分化较少，而焦虑焦虑的特异性因子的较高水平与丘脑活化的较少有关。焦虑的忧虑特异性因素的水平没有观察到任何影响。这些结果表明，与抑郁症相关的默认模式活性的改变结果可能不特异于抑郁症状，但可以更普遍地表征内化症状。此外，他们表明，较低的认知控制区域的接合可能比较低于抑郁症状的阳性影响更大。

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