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首页> 外文期刊>Investigative radiology >Intraindividual comparison of gadobenate dimeglumine and gadobutrol for cerebral magnetic resonance perfusion imaging at 1.5 T.
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Intraindividual comparison of gadobenate dimeglumine and gadobutrol for cerebral magnetic resonance perfusion imaging at 1.5 T.

机译：在1.5吨时，加苯甲酸二聚体和甘蔗酰胺脑磁共振灌注成像的特异性比较。

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RATIONALE AND OBJECTIVE: The objective of this study was to compare 0.1 and 0.2 mmol/kg body weight (bw) doses gadobenate dimeglumine (Gd-BOPTA; MultiHance) and gadobutrol (Gd-BT-DO3A; Gadovist) for cerebral perfusion magnetic resonance (MR) imaging at 1.5 T. METHODS: Twelve healthy male volunteers enrolled into a randomized intraindividual comparative study underwent 4 perfusion MR imaging examinations with 0.1 and 0.2 mmol/kg bw doses of each contrast agent. The imaging parameters, slice positioning, and contrast agent application were highly standardized. Quantitative determinations based on signal intensity/time (SI/T) curves at regions of interest (ROI) on the gray and white matter were made of the regional cerebral blood volume and flow (rCBV and rCBF, respectively), the percentage signal drop, and the full width half maximum (FWHM) of the SI/T curve. Qualitative evaluation of the quality of the rCBV and rCBF maps was assessed by an independent offsite blinded reader. RESULTS: A single dose of both agents was sufficient to achieve high-quality, diagnostically valid perfusion maps at 1.5 T, and no significant benefit for one agent over the other was noted for quantitative or qualitative determinations. The susceptibility effect, described by percentage of signal loss (gadobutrol: 29.4% vs gadobenate dimeglumine: 28.3%) and the FWHM (gadobutrol: 6.4 seconds vs gadobenate dimeglumine: 7.0 seconds) were similar for 0.1 mmol/kg bw doses of the 2 agents. Double doses of the 2 agents produced better overall image quality but no clinical benefit over the single-dose examinations. CONCLUSION: Both the 1 molar MR contrast agent gadobutrol and the weak protein-interacting agent gadobenate dimeglumine permit the acquisition of high-quality perfusion maps at doses of 0.1 mmol/kg bw. The susceptibility effect is comparable for both agents and stronger than for conventional MR contrast agents.
机译：理由和目标：本研究的目的是比较0.1和0.2mmol / kg体重（BW）剂量加入钆甲酯二苯胺（Gd-Bopta;多态）和加那蟾（Gd-BT-DO3A;凝球人）用于脑灌注磁共振（ MR）成像在1.5吨。方法：12个健康男性志愿者注册到随机内部分类的比较研究进行了4个灌注MR成像检查，每种造影剂的0.1和0.2mmol / kg BW剂量。成像参数，切片定位和造影剂应用是高度标准化的。基于灰色和白质区域（ROI）的信号强度/时间（Si / T）曲线的定量测定由区域脑血容量和流量（分别为RCBV和RCBF），百分比信号下降，和Si / T曲线的全宽半最大（FWHM）。由独立的异地盲读者评估RCBV和RCBF地图质量的定性评估。结果：单剂量的两剂量都足以实现1.5吨的高质量，诊断有效的灌注图，并且对另一个药物没有显着益处，用于定量或定性测定。易感效应，由信号损失的百分比（Gadobutrol：29.4％Vs钆二苯并：28.3％）和FWHM（甘蔗醛：6.4秒Vs钆二苯并：7.0秒）类似于2剂的0.1mmol / kg Bw剂量相似。两剂量的2剂产生更好的整体图像质量，但在单剂量检查中没有临床效益。结论：1摩尔先生造影剂Gadobutrol和弱蛋白质相互作用剂钆二苯胺允许在0.1mmol / kg Bw的剂量下采集高质量的灌注图。易感性效果对常规MR造影剂的试剂和更强的效果相当。

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