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A preliminary systematic review and meta-analysis of randomized-controlled trials of cognitive remediation therapy for anorexia nervosa

机译：厌食症治疗治疗治疗治疗的随机对照试验的初步系统综述与荟萃分析

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Cognitive remediation therapy (CRT) for anorexia nervosa (AN) was developed as an adjuvant treatment to target set-shifting and central coherence inefficiencies important in AN and to ultimately improve clinical outcomes of those with AN. The primary aim of this preliminary systematic review and meta-analysis was to determine the effect of CRT for AN relative to control treatments in randomized-controlled trials (RCTs) on neuropsychological inefficiencies at end-of-treatment. Secondary aims were to assess the effect of CRT for AN on dropout, eating-disorder-related, and other psychological outcomes at end-of-treatment. Systematic review and meta-analytic procedures were conducted in accordance with PRISMA Guidelines. RCTs evaluating CRT for AN compared to a control treatment were identified via ProQuest, PsycINFO, PubMed, and SCOPUS. Seven RCTs and one quasi-RCT of CRT for AN were included. RCT quality ratings ranged from fair (n = 3) to good (n = 4). Random-effects meta-analysis was conducted using Hedge's g. Study heterogeneity was assessed using I-2 and publication bias was assessed with Begg's adjusted-rank correlation and the trim-and-fill method. CRT was not associated with improvement in central coherence compared to control treatments at end-of-treatment (g = 0.25, 95% CI = -0.35, 0.85, k = 3). Set-shifting outcomes were mixed due to heterogeneity of set-shifting measures across studies. CRT may prevent dropout; yet, more studies are needed to draw conclusions. CRT did not confer advantage over control treatments for eating-disorder-related and other psychological outcomes at end-of-treatment. Future RCTs of CRT for AN should use precise measures to assess constructs (particularly for set shifting), increase sample size, and implement longitudinal follow-up. (Word Count: 247 words).
机译：对厌食症（AN）的认知修复治疗（CRT）被开发为辅助治疗，以靶向换档和中枢相干效率低下，最重要的是，并最终改善了那些临床结果。该初步系统审查和荟萃分析的主要目的是确定CRT在治疗结束后神经心理学无效的随机对照试验（RCT）中对照治疗的影响。次要目标是评估CRT对辍学，饮食有关的影响以及治疗结束时的其他心理结果。根据PRISMA指南进行系统审查和元分析程序。通过Proquest，Psycinfo，Pubmed和Scopus来鉴定与对照处理相比CRT的RCT。包括七个RCT和一个CRT的一个准rct。 RCT质量评级范围从公平（n = 3）到良好（n = 4）。随机效应使用对冲G进行了荟萃分析。使用I-2评估研究异质性，并通过Begg的调节秩相关评估出版物偏压和调整和填充方法。与在处理结束时的对照处理相比，CRT与中央相干性的改善无关（G = 0.25,95％CI = -0.35,0.85，K = 3）。由于研究中的设定换档措施的异质性而混合了设定的换档结果。 CRT可能会阻止辍学;然而，需要更多的研究来得出结论。 CRT没有赋予对治疗障碍相关和其他心理结果的控制治疗有限。 CRT的未来RCT应该使用精确的措施来评估构造（特别是设置换档），增加样品大小，并实施纵向随访。 （字数：247字）。

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