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首页> 外文期刊>Acute pain: international journal of acute pain management >Postoperative analgesia after caesarean section: Intermittent intramuscular versus subcutaneous morphine boluses
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Postoperative analgesia after caesarean section: Intermittent intramuscular versus subcutaneous morphine boluses

机译：剖宫产术后的镇痛：间歇性肌注与皮下注射吗啡

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Background: Several recent studies have demonstrated that the subcutaneous route of morphine administration is effective for the management of postoperative pain. The injection of morphine via an indwelling subcutaneous cannula results in blood concentrations that are comparable to those arising from intramuscular injection. The aim of this study was to compare the analgesic efficacy and adverse effect profile of intermittent intramuscular and subcutaneous morphine boluses after caesarean section. Methods: Sixty patienls, aged 16-45 years, scheduled for elective caesarean section (CS) were randomly assigned to receive analgesia via either intramuscular (IM group, 0.15mg/kg) or s.c. injections of morphine (SC group, 0.15mg/kg). Postoperative pain was assessed at rest and when moving, using a visual analogue scale (VAS) every 4h. A Mini Mental Status (MMS) examination was used to assess cognitive functions before surgery, at 2 h, 24 h and 48 h after surgery, and at hospital discharge. Side-effects were also recorded systematically during the first 48 h after surgery. Results: The SC group showed lower pain scores and higher overall analgesia satisfaction score than the IM group at rest but it was not significant statistically (P> 0.05). During mobilization, the SC group had lower pain scores and it was significant at 12 h, 16 h and 20h postoperatively (P< 0.05). There was no inter-group difference in postoperative MMS scores. The incidence of side-effects was similar in both groups. Conclusion: SC morphine is a satisfactory alternative to IM morphine after CS.
机译：背景：最近的一些研究表明，皮下注射吗啡途径可有效治疗术后疼痛。通过留置皮下套管注射吗啡导致的血药浓度与肌肉注射产生的血药浓度相当。这项研究的目的是比较剖宫产后间歇性肌注和皮下注射吗啡的镇痛效果和不良反应。方法：将60名年龄在16-45岁，计划行择期剖宫产术（CS）的患者通过肌肉注射（IM组，0.15mg / kg）或皮下注射进行镇痛。吗啡注射（SC组，0.15mg / kg）。每隔4小时使用视觉模拟量表（VAS）对静止和移动时的术后疼痛进行评估。在手术前，手术后2 h，24 h和48 h以及出院时，使用迷你心理状态（MMS）检查来评估认知功能。在手术后的第一个48小时内也有系统地记录了副作用。结果：SC组在静息状态下的疼痛评分较低，而总镇痛满意度高于IM组，但差异无统计学意义（P> 0.05）。动员期间，SC组的疼痛评分较低，并且在术后12 h，16 h和20 h显着（P <0.05）。术后MMS评分无组间差异。两组的副作用发生率相似。结论：CS后，SC吗啡可以替代IM吗啡。

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