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首页> 外文期刊>BJU international >Slow progress in prostate cancer.
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Slow progress in prostate cancer.

机译:前列腺癌进展缓慢。

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摘要

At the turn of the last century the results of the prostate cancer prevention trial (PCPT) were eagerly anticipated. In that study the impact of the 5a-reductase inhibitor (5ARI), finasteride on the long-term progression of prostate cancer was under evaluation. In June 2003, the PCPT was stopped early because of a clear finding that finasteride reduced the incidence of prostate cancer. However, the study appeared to produce equivocal results, as there could have been a potential 'downside'; those trial participants who developed prostate cancer while taking finasteride had a slightly higher incidence of high-grade tumours. Researchers are continuing to analyse the data to find out whether finasteride actually caused high-grade tumours.
机译:在上个世纪之交,人们迫切期望前列腺癌预防试验(PCPT)的结果。在该研究中,正在评估5a-还原酶抑制剂(5ARI),非那雄胺对前列腺癌长期进展的影响。 2003年6月,由于明确发现非那雄胺降低了前列腺癌的发生率,PCPT提前终止。然而,这项研究似乎产生了模棱两可的结果,因为可能存在潜在的“不利因素”。那些服用非那雄胺同时患上前列腺癌的试验参与者发生高级别肿瘤的几率更高。研究人员正在继续分析数据,以查找非那雄胺是否确实引起了高级别的肿瘤。

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