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首页> 外文期刊>BJU international >An animal model to study lower urinary tract symptoms and erectile dysfunction: the hyperlipidaemic rat.
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An animal model to study lower urinary tract symptoms and erectile dysfunction: the hyperlipidaemic rat.

机译：研究下尿路症状和勃起功能障碍的动物模型：高脂血症大鼠。

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OBJECTIVE To present evidence that rats fed a high-fat diet could serve as a useful animal model to study both lower urinary tract symptoms (LUTS) and erectile dysfunction (ED), as recent epidemiological studies have shown a strong association between LUTS and ED but the physiological basis behind this relationship is unknown. MATERIALS AND METHODS In all, 24 male Sprague-Dawley rats were divided into two groups: nine controls were fed a 'normal' diet and 15 were fed a high-fat diet (hyperlipidaemic rats). After 6 months all the rats had bladder and erectile functions evaluated using awake cystometry and cavernosal nerve electrostimulation, respectively. After the functional studies were completed, the penis, prostate and bladder were collected for immunohistochemical analysis. RESULTS The hyperlipidaemic rats had significantly higher serum cholesterol and low-density lipoprotein than the controls (P < 0.05). The hyperlipidaemic rats also had significantly worse erectile function (P = 0.004) and developed more bladder overactivity (P = 0.004) than the controls. In the hyperlipidaemic rats there was significant muscle hypertrophy in the peri-urethral lobe of the prostate (P < 0.001) and in the bladder (P < 0.05). There was also greater P2X(1) (purinoceptor) staining as well as other molecular changes in the bladder of the hyperlipidaemic rats. CONCLUSIONS In this hyperlipidaemic rat model three abnormalities were consistently detected: prostatic enlargement, bladder overactivity, and ED. This rat model could be a useful research tool for understanding the common causes of LUTS and ED, as well as facilitating the development of preventive measures and better therapies to treat both conditions.
机译：目的提供证据证明高脂饮食的大鼠可以作为研究下尿路症状（LUTS）和勃起功能障碍（ED）的有用动物模型，因为最近的流行病学研究表明，LUTS和ED之间存在很强的联系，但这种关系背后的生理基础是未知的。材料和方法总共将24只雄性Sprague-Dawley大鼠分为两组：向9个对照组喂食“正常”饮食，向15个大鼠喂食高脂饮食（高脂血症大鼠）。 6个月后，所有大鼠的膀胱和勃起功能分别通过清醒膀胱测压法和海绵体神经电刺激评估。功能研究完成后，收集阴茎，前列腺和膀胱进行免疫组织化学分析。结果高脂血症大鼠的血清胆固醇和低密度脂蛋白明显高于对照组（P <0.05）。高脂血症大鼠的勃起功能也显着较差（P = 0.004），并且比对照组有更多的膀胱过度活动（P = 0.004）。在高脂血症大鼠中，前列腺的尿道周旁叶（P <0.001）和膀胱（P <0.05）有明显的肌肉肥大。高脂血症大鼠膀胱中的P2X（1）（嘌呤受体）染色以及其他分子变化也更大。结论在该高脂血症大鼠模型中，始终检测到三个异常：前列腺肥大，膀胱过度活动症和ED。该大鼠模型可能是了解LUTS和ED的常见原因以及促进制定预防措施和更好的疗法来治疗这两种情况的有用研究工具。

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