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首页> 外文期刊>International journal of dermatology >Human papillomavirus‐associated cutaneous disease burden in human immunodeficiency virus (HIV)‐positive patients: the role of human papillomavirus vaccination and a review of the literature
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Human papillomavirus‐associated cutaneous disease burden in human immunodeficiency virus (HIV)‐positive patients: the role of human papillomavirus vaccination and a review of the literature

机译：人类免疫缺陷病毒（艾滋病毒） - 阳性患者的人乳头瘤病毒相关皮肤病负担：人乳头瘤病毒疫苗接种的作用及文献综述

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Abstract Human papillomavirus ( HPV ) infection is related to the development of cutaneous squamous cell carcinoma, oropharyngeal carcinoma, and anogenital malignancies. Patients infected with human immunodeficiency virus ( HIV ) have impaired cell‐mediated immunity, placing them at risk for more prolonged infection with a greater likelihood of disease expression. This presents important implications for screening and treatment of HPV in the HIV patient population. The use of prophylactic vaccines directed against HPV has been a promising clinical development, though the immunogenicity of these vaccines in the immunocompromised host and in patients with previously established HPV infections has not been well established. In this review, we describe the pathogenesis and epidemiology of HPV ‐related cutaneous malignancies in patients with HIV . We outline the current guidelines and recent advances in the field of HPV vaccination. It is our hope that increasing awareness of the HPV ‐related HIV comorbidities will lead to developments in preventative medicine capable of reducing the burden of these diseases. We recognize the importance of prevention as a primary defense against disease and hope that this article organizes and disseminates recent findings in the field of HPV ‐associated comorbidities in the HIV population.
机译：摘要人乳头瘤病毒（HPV）感染与皮肤鳞状细胞癌，口咽癌和源性恶性肿瘤的发展有关。感染人类免疫缺陷病毒（HIV）的患者患有细胞介导的免疫力受损，将它们处于危险的风险，以更长的感染具有更大的疾病表达可能性。这提出了对艾滋病毒患者人群中HPV进行筛选和治疗的重要意义。针对HPV指导的预防性疫苗一直是一项有前途的临床发展，尽管这些疫苗在免疫疗法宿主和先前建立的HPV感染患者中的免疫原性并未得到很好的成熟。在本综述中，我们描述了HIV患者HPV -Reled皮肤恶性肿瘤的发病机制和流行病学。我们概述了HPV疫苗接种领域的现行指导方针和最近进展。我们希望增加对HPV -Reled HIV可变性的认识将导致预防性药物的发展能够降低这些疾病的负担。我们认识到预防作为对疾病的主要防御的重要性，并希望本条在艾滋病毒人群中组织和传播最近的HPV群体群体的研究结果。

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